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Literature summary extracted from

  • Tiralongo, J.; Schauer, R.
    The enigma of enzymatic sialic acid O-acetylation (2004), Trends Glycosci. Glycotechnol., 16, 1-15.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.45 additional information membrane integrity is required Cavia porcellus
2.3.1.45 additional information membrane integrity is required Mus musculus
2.3.1.45 additional information membrane integrity is required Homo sapiens
2.3.1.45 additional information membrane integrity is required Rattus norvegicus
2.3.1.45 additional information membrane integrity is required Bos taurus
2.3.1.45 additional information membrane integrity is required Equus caballus

Protein Variants

EC Number Protein Variants Comment Organism
2.3.1.45 additional information a transgenic mouse where O-acetylated GD3 is absent, shows a disruption in organogenesis, suggesting a role for O-acetylated GD3 in cellular differentiation Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.45 CoA
-
 Bos taurus
2.3.1.45 CoA
-
 Equus caballus
2.3.1.45 CoA
-
 Homo sapiens
2.3.1.45 CoA
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.45 0.0016
-
 acetyl-CoA pH 7.0, 37°C Bos taurus
2.3.1.45 0.0029
-
 acetyl-CoA pH 7.0, 22°C Rattus norvegicus
2.3.1.45 0.0036
-
 acetyl-CoA pH 5.6, 30°C Cavia porcellus
2.3.1.45 0.0061
-
 acetyl-CoA pH 7.0, 37°C Homo sapiens
2.3.1.45 0.0321
-
 acetyl-CoA pH 6.6, 37°C Equus caballus
2.3.1.45 0.0592
-
 CMP-5-N-acetylneuraminic acid pH 7.0, 37°C Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.45 Golgi vesicle membrane integrity is required Mus musculus
-
-
2.3.1.45 Golgi vesicle membrane integrity is required Homo sapiens
-
-
2.3.1.45 Golgi vesicle membrane integrity is required Rattus norvegicus
-
-
2.3.1.45 Golgi vesicle membrane integrity is required Bos taurus
-
-
2.3.1.45 Golgi vesicle membrane integrity is required Equus caballus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Cavia porcellus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Mus musculus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Rattus norvegicus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Bos taurus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Equus caballus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Cavia porcellus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Rattus norvegicus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Bos taurus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Equus caballus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Mus musculus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Cavia porcellus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Mus musculus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Rattus norvegicus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Bos taurus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid Equus caballus tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid Homo sapiens tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid Homo sapiens tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid Homo sapiens tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 additional information Cavia porcellus Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, one acceptor substrate is GD3, overview ?
-
 ?
2.3.1.45 additional information Rattus norvegicus Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview ?
-
 ?
2.3.1.45 additional information Bos taurus Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview ?
-
 ?
2.3.1.45 additional information Equus caballus Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview ?
-
 ?
2.3.1.45 additional information Homo sapiens Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, enzyme role in regulation, the enzyme colaborates with the sialate O-acetylesterase, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview ?
-
 ?
2.3.1.45 additional information Mus musculus Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.45 Bos taurus
-
-
-
2.3.1.45 Cavia porcellus
-
-
-
2.3.1.45 Equus caballus
-
-
-
2.3.1.45 Homo sapiens
-
-
-
2.3.1.45 Mus musculus
-
-
-
2.3.1.45 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.45 basalioma cell
-
 Homo sapiens
-
2.3.1.45 breast cancer cell
-
 Homo sapiens
-
2.3.1.45 colon mucosa Homo sapiens
-
2.3.1.45 colorectal cancer cell
-
 Homo sapiens
-
2.3.1.45 liver
-
 Cavia porcellus
-
2.3.1.45 liver
-
 Rattus norvegicus
-
2.3.1.45 melanoma cell sialic acid O-acetylation levels in different samples, overview Homo sapiens
-
2.3.1.45 additional information high expression of O-acetylated GD3 occurs in human basalioma and melanoma Homo sapiens
-
2.3.1.45 skin sialic acid O-acetylation levels in different samples, overview Homo sapiens
-
2.3.1.45 submandibular gland
-
 Mus musculus
-
2.3.1.45 submandibular gland
-
 Bos taurus
-
2.3.1.45 submandibular gland
-
 Equus caballus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Cavia porcellus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Mus musculus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Rattus norvegicus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Bos taurus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Equus caballus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Cavia porcellus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Mus musculus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Rattus norvegicus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Bos taurus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Equus caballus CoA + 5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Cavia porcellus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Mus musculus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Rattus norvegicus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Bos taurus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Equus caballus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Cavia porcellus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Rattus norvegicus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Bos taurus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Equus caballus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. in regulation of cancer development via GD3-O-acetylation, overview Mus musculus CoA + 5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Cavia porcellus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Mus musculus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Rattus norvegicus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Bos taurus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid
-
 Equus caballus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Cavia porcellus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Mus musculus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Rattus norvegicus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Bos taurus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + 5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Equus caballus CoA + 5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid
-
 Homo sapiens CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes Homo sapiens CoA + CMP-5-N-acetyl-7-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid
-
 Homo sapiens CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. terminal alpha2,8-linked sialic acid occurs on the glycerol side chain of GD3, where it reverses FAS-mediated apoptotic effects, suggesting a role of GD3 O-acetylation in regulating induced apoptosis, GD2 O-acetylation is oberseved in breast cancer Homo sapiens CoA + CMP-5-N-acetyl-8-O-acetyl-neuraminate
-
 ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid
-
 Homo sapiens CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate 9-O-acetyl sialic acids may occur via isomeriaztion of 7-O-acetyl sialic acids ?
2.3.1.45 acetyl-CoA + CMP-5-N-acetylneuraminic acid tissue- and cell type-specific modification of sialic acids, often in a development-dependent manner, plays a pivotal role in modulating various biological processes, e.g. via 9-O-acetylation on colonic mucins, overview Homo sapiens CoA + CMP-5-N-acetyl-9-O-acetyl-neuraminate
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, one acceptor substrate is GD3, overview Cavia porcellus ?
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview Rattus norvegicus ?
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview Bos taurus ?
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview Equus caballus ?
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, enzyme role in regulation, the enzyme colaborates with the sialate O-acetylesterase, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview Homo sapiens ?
-
 ?
2.3.1.45 additional information Golgi O-acetylation pathway, overview, the enzyme is involved in cancer development, overview, reaction mechanism and supply of acetyl-CoA for the acetylation within the Golgi lumen, overview Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.45 7(9)-OAT
-
 Cavia porcellus
2.3.1.45 7(9)-OAT
-
 Mus musculus
2.3.1.45 7(9)-OAT
-
 Homo sapiens
2.3.1.45 7(9)-OAT
-
 Rattus norvegicus
2.3.1.45 7(9)-OAT
-
 Bos taurus
2.3.1.45 7(9)-OAT
-
 Equus caballus
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Cavia porcellus
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Mus musculus
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Homo sapiens
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Rattus norvegicus
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Bos taurus
2.3.1.45 sialate-7(9)-O-acetyltransferase
-
 Equus caballus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.45 22
-
-
 Rattus norvegicus
2.3.1.45 30
-
-
 Cavia porcellus
2.3.1.45 37
-
-
 Homo sapiens
2.3.1.45 37
-
-
 Bos taurus
2.3.1.45 37
-
-
 Equus caballus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.45 5.6
-
-
 Cavia porcellus
2.3.1.45 6.6
-
-
 Equus caballus
2.3.1.45 7
-
-
 Homo sapiens
2.3.1.45 7
-
-
 Rattus norvegicus
2.3.1.45 7
-
-
 Bos taurus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.45 acetyl-CoA
-
 Cavia porcellus
2.3.1.45 acetyl-CoA
-
 Mus musculus
2.3.1.45 acetyl-CoA
-
 Homo sapiens
2.3.1.45 acetyl-CoA
-
 Rattus norvegicus
2.3.1.45 acetyl-CoA
-
 Bos taurus
2.3.1.45 acetyl-CoA
-
 Equus caballus