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Literature summary extracted from

  • Short, D.M.; Lyon, R.; Watson, D.G.; Barski, O.A.; McGarvie, G.; Ellis, E.M.
    Metabolism of trans, trans-muconaldehyde, acytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4 (2006), Toxicol. Appl. Pharmacol., 210, 163-170.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.2 expression in vector pET28a Mus musculus
1.2.1.4 into the pET28a vector for expression in Escherichia coli Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.2 pyrazole
-
Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.2 15
-
(2E,4E)-hexa-2,4-dienal pH 7.4, 25°C, with NAD(P)H Mus musculus
1.2.1.4 0.015
-
muconaldehyde
-
Mus musculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.4 37000
-
predicted Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.4 an aldehyde + NADP+ + H2O Mus musculus
-
an acid + NADPH + H+
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.2 Mus musculus
-
-
-
1.2.1.4 Mus musculus Q540D7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.2.1.4 using a Q-sepharose anion exchange column for enzyme preparation of mouse liver, using nickel agarose affinity chromatography for purification of recombinant protein Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.2 liver
-
Mus musculus
-
1.2.1.4 liver
-
Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.2 (2E,4E)-hexa-2,4-dienal + NAD(P)H + H+
-
Mus musculus (2E,4E)-6-hydroxyhexa-2,4-dienal + NAD(P)+
-
?
1.2.1.4 an aldehyde + NADP+ + H2O
-
Mus musculus an acid + NADPH + H+
-
?
1.2.1.4 trans,trans-muconaldehyde + NADP+ + H2O
-
Mus musculus trans,trans-muconic acid + NADPH + H+
-
?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.2 AKR1A4
-
Mus musculus
1.2.1.4 AKR1A4
-
Mus musculus
1.2.1.4 aldehyde dehydrogenase (NADP+)
-
Mus musculus
1.2.1.4 aldehyde reductase
-
Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.2 25
-
assay temperature Mus musculus
1.2.1.4 37
-
activity assay Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.4 7.4
-
activity assay Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.2 NADPH
-
Mus musculus
1.2.1.4 NADPH
-
Mus musculus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.2 additional information
-
pyrazole substrate: (2E,4E)-hexa-2,4-dienal, uncompetitive inhibition Mus musculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.2.1.4 Mus musculus
-
-
7.2