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Literature summary extracted from

  • Humljan, J.; Kotnik, M.; Boniface, A.; Solmajer, T.; Urleb, U.; Blanot, D.; Gobec, S.
    A new approach towards peptidosulfonamides: synthesis of potential inhibitors of bacterial peptidoglycan biosynthesis enzymes MurD and MurE (2006), Tetrahedron, 62, 10980-10988.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.9 N-([(2S)-2-[(2-naphthylsulfonyl)amino]propyl]-sulfonyl)-D-glutamic acid 1 mM, 75% residual activity Escherichia coli
6.3.2.9 N-([(2S)-2-[([1,1'-biphenyl]-4-yl-sulfonyl)amino]-propyl]sulfonyl)-D-glutamic acid 1 mM, 70% residual activity Escherichia coli
6.3.2.9 N-[((2S)-2-[[(E)-3-(1,3-benzodioxol-5-yl)-2-propenoyl]amino]propyl)sulfonyl]-D-glutamic acid 1 mM, 80% residual activity Escherichia coli
6.3.2.9 N-[[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]sulfonyl]-D-glutamic acid 1 mM, 74% residual activity Escherichia coli
6.3.2.9 N-[[(2S)-2-([2-[2-(acetylamino)phenoxy]acetyl]-amino)propyl]sulfonyl]-D-glutamic acid 1 mM, 93% residual activity Escherichia coli
6.3.2.9 N-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl]sulfonyl]-D-glutamic acid 1 mM, 77% residual activity Escherichia coli
6.3.2.13 N-([(2S)-2-[(2-naphthylsulfonyl)amino]propyl]-sulfonyl)-D-glutamic acid 60% residual activity at 1 mM Staphylococcus aureus
6.3.2.13 N-([(2S)-2-[([1,1'-biphenyl]-4-yl-sulfonyl)amino]-propyl]sulfonyl)-D-glutamic acid 12% residual activity at 1 mM Staphylococcus aureus
6.3.2.13 N-[((2S)-2-[[(E)-3-(1,3-benzodioxol-5-yl)-2-propenoyl]amino]propyl)sulfonyl]-D-glutamic acid 64% residual activity at 1 mM Staphylococcus aureus
6.3.2.13 N-[[(2S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propyl]sulfonyl]-D-glutamic acid 41% residual activity at 1 mM Staphylococcus aureus
6.3.2.13 N-[[(2S)-2-([2-[2-(acetylamino)phenoxy]acetyl]-amino)propyl]sulfonyl]-D-glutamic acid 56% residual activity at 1 mM Staphylococcus aureus
6.3.2.13 N-[[2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-ethyl]sulfonyl]-D-glutamic acid 1 mM Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.9 Escherichia coli
-
-
-
6.3.2.13 Staphylococcus aureus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.13 ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + L-lysine
-
Staphylococcus aureus ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-L-lysine
-
?

Synonyms

EC Number Synonyms Comment Organism
6.3.2.9 MurD
-
Escherichia coli
6.3.2.13 MurE
-
Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.3.2.13 0.181
-
at 37°C Staphylococcus aureus indol-3-ylmethyl isothiocyanate