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Literature summary extracted from

  • Martin, D.W.
    Structure-function relationships in the Na+,K+-pump (2005), Semin. Nephrol., 25, 282-291.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
7.2.2.13 refinement to 9-11 A Mammalia

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.13 Ouabain interaction is dependent on the conformation and phosphorylation state of the protein Mammalia

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
7.2.2.13 7000
-
 gamma subunit: 6500-7500 Da, identified in kidney tissue Mammalia
7.2.2.13 35000
-
 beta subunit Mammalia
7.2.2.13 112000
-
 alpha subunit Mammalia

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out Mammalia each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP ATP + H2O + Na+/in
-
 r
7.2.2.13 ATP + H2O + K+/in Mammalia
-
 ADP + phosphate + K+/out
-
 r

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.13 Mammalia
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
7.2.2.13 glycoprotein beta subunit Mammalia

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.13 ADP + phosphate + Na+/out each cycle extrudes 3 Na+ from the cell and moves 2 K+ into the cell with utilization of 1 ATP Mammalia ATP + H2O + Na+/in
-
 r
7.2.2.13 ADP + phosphate + Na+/out
-
 Mammalia ATP + H2O + Na+/in
-
 r
7.2.2.13 ATP + H2O + K+/in
-
 Mammalia ADP + phosphate + K+/out
-
 r

Subunits

EC Number Subunits Comment Organism
7.2.2.13 dimer alphabeta, minimal functional unit, aggrgation of protomeric units is a common observation Mammalia
7.2.2.13 trimer alphabetagamma Mammalia

Synonyms

EC Number Synonyms Comment Organism
7.2.2.13 Na(+)-K(+)-exchanging ATPase
-
 Mammalia
7.2.2.13 Na+,K+-adenosine triphosphatase
-
 Mammalia
7.2.2.13 Na+,K+-ATPase
-
 Mammalia
7.2.2.13 Na+,K+-pump
-
 Mammalia
7.2.2.13 Na,K-Pump
-
 Mammalia