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Literature summary extracted from

  • Molnar, C.; Holguin, H.; Mayor, F.; Ruiz-Gomez, A.; de Celis, J.F.
    The G protein-coupled receptor regulatory kinase GPRK2 participates in Hedgehog signaling in Drosophila (2007), Proc. Natl. Acad. Sci. USA, 104, 7963-7968.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.15 expression of GRK2-fusion constructs in transgenic flies, expression analysis, overview Drosophila melanogaster

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.15 additional information lowering Gprk2 levels in the wing disc reduces the expression of Smo targets and causes a phenotype reminiscent of loss of Smo function, phenotype, overview Drosophila melanogaster
2.7.11.15 additional information generation of a Gprk2 deficiency, phenotype, overview Drosophila melanogaster

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.15 membrane
-
 Drosophila melanogaster 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.15 Mg2+
-
 Drosophila melanogaster

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.15 ATP + Smo Drosophila melanogaster GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview ADP + phosphorylated Smo
-
 ?
2.7.11.15 additional information Drosophila melanogaster Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.15 Drosophila melanogaster
-
 gene Gprk2
-
2.7.11.15 Drosophila melanogaster P32866
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.15 S2 cell
-
 Drosophila melanogaster
-
2.7.11.15 wing
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.15 ATP + Smo
-
 Drosophila melanogaster ADP + phosphorylated Smo
-
 ?
2.7.11.15 ATP + Smo GPRK2 participates in Hedgehog signaling in Drosophila melanogaster, and plays a key role in the Smo signal transduction pathway, when Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced, overview Drosophila melanogaster ADP + phosphorylated Smo
-
 ?
2.7.11.15 additional information Gprk2, a Drosophila member of the G protein-coupled receptor kinases, plays a key role in the Smo, i.e. Smoothened, signal transduction pathway, overview. When Gprk2 levels are lowered, Smo still accumulates at the cell membrane, but its activation is reduced. Regulation of Gprk2 expression by Hh signaling in the wing disc, but Gprk2 is also required for Hh signaling in the wing disc, overview Drosophila melanogaster ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.15 G protein-coupled receptor regulatory kinase
-
 Drosophila melanogaster
2.7.11.15 G protein-coupled receptor regulatory kinase 2
-
 Drosophila melanogaster
2.7.11.15 Gprk2
-
 Drosophila melanogaster

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.15 ATP
-
 Drosophila melanogaster