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Literature summary extracted from

  • Liu, B.; Raeth, T.; Beuerle, T.; Beerhues, L.
    Biphenyl synthase, a novel type III polyketide synthase (2007), Planta, 225, 1495-1503.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.3.1.177
-
 Sorbus aucuparia

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.177 0.7
-
 benzoyl-CoA pH 7.0, 35°C Sorbus aucuparia
2.3.1.177 6.2
-
 malonyl-CoA pH 7.0, 35°C Sorbus aucuparia

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.177 Sorbus aucuparia Q27Z07 enzyme expression is rapidly, strongly and transiently induced by yeast extract treatment
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.177 malonyl-CoA + 2-hydroxybenzoyl-CoA 52% of the activity with benzoyl-CoA Sorbus aucuparia CoA + 2-hydroxybenzoyltriacetic acid lactone + CO2
-
 ?
2.3.1.177 malonyl-CoA + 3-hydroxybenzoyl-CoA 68% of the activity with benzoyl-CoA Sorbus aucuparia CoA + ? + CO2
-
 ?
2.3.1.177 malonyl-CoA + benzoyl-CoA
-
 Sorbus aucuparia CoA + 3,5-dihydroxybiphenyl + CO2 low amounts of benzoyldiacetic acid lactone are synthesized as derailment product ?
2.3.1.177 additional information benzoyl-CoA is the preferred starter substrate. Enzyme does not accept 4-hydroxybenzoyl-CoA or CoA-linked cinnamic acids such as 4-coumaroyl-CoA Sorbus aucuparia ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.177 35
-
-
 Sorbus aucuparia

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.1.177 0.0072
-
 benzoyl-CoA pH 7.0, 35°C Sorbus aucuparia

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.177 6.5 7
-
 Sorbus aucuparia