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Literature summary extracted from
- Identification of a low vindoline accumulating cultivar of Catharanthus roseus (L.) G. Don by alkaloid and enzymatic profiling (2006), Phytochemistry, 67, 1758-1764.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.103 | additional information | Catharanthus roseus | alkaloid and enzymatic profiling of the vindoline biosynthetic pathway, overview | ? | - |
? |  |
| 1.14.14.103 | tabersonine + NADPH + H+ + O2 | Catharanthus roseus | step in monoterpenoid indole alkaloid biosynthesis, biosynthesis of anticancer dimeric alkaloids vinblastine and vincristine, overview | 16-hydroxytabersonine + NADP+ + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.14.103 | Catharanthus roseus | - |
50 different flowering cultivars, one low vindoline accumulating cultivar Little Delicata | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.14.103 | leaf | young | Catharanthus roseus | - |
| 1.14.14.103 | seedling | - |
Catharanthus roseus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.14.103 | additional information | alkaloid and enzymatic profiling of the vindoline biosynthetic pathway, overview | Catharanthus roseus | ? | - |
? | |
| 1.14.14.103 | tabersonine + NADPH + H+ + O2 | - |
Catharanthus roseus | 16-hydroxytabersonine + NADP+ + H2O | - |
? | |
| 1.14.14.103 | tabersonine + NADPH + H+ + O2 | step in monoterpenoid indole alkaloid biosynthesis, biosynthesis of anticancer dimeric alkaloids vinblastine and vincristine, overview | Catharanthus roseus | 16-hydroxytabersonine + NADP+ + H2O | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.103 | 37 | - |
assay at | Catharanthus roseus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.14.103 | 8 | - |
assay at | Catharanthus roseus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.14.103 | cytochrome P450 | - |
Catharanthus roseus |
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Release 2023.1 (January 2023)
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