EC Number | Application | Comment | Organism |
---|---|---|---|
2.3.1.161 | medicine | lovastatin is a fungal polyketide metabolite produced by Aspergillus terreus that has been used as a drug to lower cholesterol levels | Aspergillus terreus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.3.1.161 | additional information | - |
additional information | in absence of accessory protein LovC, enzyme forms truncated pyrones 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one. Chemical synthesis of these truncated pyrones for analysis of enzyme reaction | Aspergillus terreus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.161 | Mg2+ | - |
Aspergillus terreus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | Aspergillus terreus | in the presence of the accessory protein LovC | dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O | - |
? | |
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | Aspergillus terreus | in the absence of the accessory protein LovC, LovB forms conjugated pyrones as truncated polyketide synthase products | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.161 | Aspergillus terreus | - |
- |
- |
2.3.1.161 | Aspergillus terreus | Q9Y8A5 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | - |
Aspergillus terreus | dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O | in presence of accessory protein LovC, formation of dihydrononacolin C | ? | |
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | in the presence of the accessory protein LovC | Aspergillus terreus | dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O | - |
? | |
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | - |
Aspergillus terreus | 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O | in absence of accessory protein LovC, formation of truncated pyrones 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one. Chemical synthesis of these truncated pyrones for analysis of enzyme reaction | ? | |
2.3.1.161 | acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine | in the absence of the accessory protein LovC, LovB forms conjugated pyrones as truncated polyketide synthase products | Aspergillus terreus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.3.1.161 | LNKS | - |
Aspergillus terreus |
2.3.1.161 | lovastatin nonaketide synthase | - |
Aspergillus terreus |
2.3.1.161 | LovB | - |
Aspergillus terreus |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.161 | NADPH | - |
Aspergillus terreus |