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Literature summary extracted from

  • Burr, D.A.; Chen, X.B.; Vederas, J.C.
    Syntheses of conjugated pyrones for the enzymatic assay of lovastatin nonaketide synthase, an iterative polyketide synthase (2007), Org. Lett., 9, 161-164.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.3.1.161 medicine lovastatin is a fungal polyketide metabolite produced by Aspergillus terreus that has been used as a drug to lower cholesterol levels Aspergillus terreus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.161 additional information
-
additional information in absence of accessory protein LovC, enzyme forms truncated pyrones 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one. Chemical synthesis of these truncated pyrones for analysis of enzyme reaction Aspergillus terreus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.3.1.161 Mg2+
-
Aspergillus terreus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine Aspergillus terreus in the presence of the accessory protein LovC dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O
-
?
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine Aspergillus terreus in the absence of the accessory protein LovC, LovB forms conjugated pyrones as truncated polyketide synthase products ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.161 Aspergillus terreus
-
-
-
2.3.1.161 Aspergillus terreus Q9Y8A5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine
-
Aspergillus terreus dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O in presence of accessory protein LovC, formation of dihydrononacolin C ?
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine in the presence of the accessory protein LovC Aspergillus terreus dihydromonacolin L + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O
-
?
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine
-
Aspergillus terreus 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one + CoA + CO2 + NADP+ + S-adenosyl-L-homocysteine + H2O in absence of accessory protein LovC, formation of truncated pyrones 4-hydroxy-6-[(1E,3E,5E)-1-methylhepta-1,3,5-trien-1-yl]-2H-pyran-2-one + 4-hydroxy-6-[(1E,3E,5E,7E)-3-methylnona-1,3,5,7-tetraen-1-yl]-2H-pyran-2-one. Chemical synthesis of these truncated pyrones for analysis of enzyme reaction ?
2.3.1.161 acetyl-CoA + malonyl-CoA + NADPH + H+ + S-adenosyl-L-methionine in the absence of the accessory protein LovC, LovB forms conjugated pyrones as truncated polyketide synthase products Aspergillus terreus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.161 LNKS
-
Aspergillus terreus
2.3.1.161 lovastatin nonaketide synthase
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Aspergillus terreus
2.3.1.161 LovB
-
Aspergillus terreus

Cofactor

EC Number Cofactor Comment Organism Structure
2.3.1.161 NADPH
-
Aspergillus terreus