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Literature summary extracted from

  • Qiu, Y.; Li, D.
    Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase (2006), Org. Lett., 8, 1013-1016.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.36 (3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
 Rattus norvegicus
2.7.1.36 (3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
 Rattus norvegicus
2.7.1.36 8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid
-
 Rattus norvegicus
2.7.1.36 geranyl diphosphate
-
 Rattus norvegicus
2.7.1.36 mevalonate 5-diphosphate
-
 Rattus norvegicus
2.7.1.36 additional information organic synthesis of bisubstrate analogues, organic synthesis and biological characterization of bifunctional molecules, which can inhibit both MVK and mevalonate 5-diphosphate decarboxylase Rattus norvegicus
2.7.1.36 P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate
-
 Rattus norvegicus
2.7.1.36 P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
 Rattus norvegicus
2.7.1.36 P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate
-
 Rattus norvegicus
2.7.1.36 P'-geranyl octanate 8-diphosphate
-
 Rattus norvegicus
4.1.1.33 (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
-
 Rattus norvegicus
4.1.1.33 (2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate
-
 Rattus norvegicus
4.1.1.33 P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
-
 Rattus norvegicus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.36 Mg2+
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate Rattus norvegicus a step in the mevalonate pathway, overview ADP + (R)-5-phosphomevalonate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.36 Rattus norvegicus
-
-
-
4.1.1.33 Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.36 ATP + (R)-mevalonate
-
 Rattus norvegicus ADP + (R)-5-phosphomevalonate
-
 ?
2.7.1.36 ATP + (R)-mevalonate a step in the mevalonate pathway, overview Rattus norvegicus ADP + (R)-5-phosphomevalonate
-
 ?
4.1.1.33 ATP + 5-diphosphomevalonate
-
 Rattus norvegicus ADP + phosphate + isopentenyl diphosphate + CO2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.36 MVK
-
 Rattus norvegicus
4.1.1.33 MDD
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.36 ATP
-
 Rattus norvegicus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.1.36 0.0025
-
 pH 7.0, 30°C Rattus norvegicus (3S),(5R)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
2.7.1.36 0.0038
-
 pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
2.7.1.36 0.0039
-
 pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,9-trihydroxy-3-methylnonanate 9-diphosphate
2.7.1.36 0.005
-
-
 Rattus norvegicus geranyl diphosphate
2.7.1.36 0.0055
-
 pH 7.0, 30°C Rattus norvegicus P'-geranyl octanate 8-diphosphate
2.7.1.36 0.0075
-
 pH 7.0, 30°C Rattus norvegicus (3R),(5S)-P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
2.7.1.36 0.008
-
 pH 7.0, 30°C Rattus norvegicus P'-geranyl 3,5,7-trihydroxy-3-methylheptanate 7-diphosphate
2.7.1.36 0.18
-
-
 Rattus norvegicus mevalonate 5-diphosphate
2.7.1.36 0.45
-
 pH 7.0, 30°C Rattus norvegicus 8-[[hydroxy(phosphonooxy)phosphoryl]oxy]octanoic acid
4.1.1.33 0.002
-
-
 Rattus norvegicus P'-geranyl 3,5,8-trihydroxy-3-methyloctanate 8-diphosphate
4.1.1.33 0.0026
-
-
 Rattus norvegicus (2E)-3,7-dimethylocta-2,6-dien-1-yl 2-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)ethyl diphosphate
4.1.1.33 0.0065
-
-
 Rattus norvegicus (2E)-3,7-dimethylocta-2,6-dien-1-yl 4-(4-hydroxy-4-methyl-6-oxotetrahydro-2H-pyran-2-yl)butyl diphosphate