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Literature summary extracted from

  • Tuck, K.L.; Saldanha, S.A.; Birch, L.M.; Smith, A.G.; Abell, C.
    The design and synthesis of inhibitors of pantothenate synthetase (2006), Org. Biomol. Chem., 4, 3598-3610.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.3.2.1 (2RS)-5'-O-(2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine
-
 Escherichia coli
6.3.2.1 (2RS)-5'-O-(3,3-dimethyl-2-aminobutyrylsulfamoyl)adenosine
-
 Escherichia coli
6.3.2.1 (2RS)-5'-O-(3,3-dimethyl-2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine
-
 Escherichia coli
6.3.2.1 (2RS)-5'-O-(3,3-dimethyl-2-hydroxybutyrylsulfamoyl)adenosine
-
 Escherichia coli
6.3.2.1 (2RS)-5'-O-(3,3-dimethyl-2-oxobutyrylsulfamoyl)adenosine
-
 Escherichia coli
6.3.2.1 (2RS)-adenosyl-2-hydroxy-3,3-dimethylbuyrate
-
 Escherichia coli
6.3.2.1 (2RS)-adenosyl-2-hydroxy-4-methoxybutyrate
-
 Escherichia coli
6.3.2.1 (2RS)-adenosyl-3,3-dimethyl-2-hydroxy-4-methoxybutyrate
-
 Escherichia coli
6.3.2.1 (2S)-adenosyl-2-L-amino-3,3-dimethylbutanoate
-
 Escherichia coli
6.3.2.1 3,3-dimethyl-2-oxobutyric acid 5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl ester
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
6.3.2.1 0.31
-
 beta-Alanine 25°C Escherichia coli
6.3.2.1 1.45
-
 (R)-pantoate 25°C Escherichia coli
6.3.2.1 1.75
-
 ATP 25°C Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
6.3.2.1 Escherichia coli P31663
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
6.3.2.1 ATP + (R)-pantoate + beta-alanine
-
 Escherichia coli AMP + diphosphate + (R)-pantothenate
-
 ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6.3.2.1 1.4
-
 ATP 25°C Escherichia coli
6.3.2.1 1.4
-
 beta-Alanine 25°C Escherichia coli
6.3.2.1 1.4
-
 (R)-pantoate 25°C Escherichia coli

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
6.3.2.1 0.0003
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.0008
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.0008
-
 (2RS)-5'-O-(2-hydroxy-4-methoxybutyrylsulfamoyl) adenosine 25°C Escherichia coli
6.3.2.1 0.0011
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.014
-
 (2RS)-5'-O-(3,3-dimethyl-2-oxobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.015
-
 (2RS)-5'-O-(3,3-dimethyl-2-oxobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.03
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.054
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.065
-
 (2RS)-5'-O-(3,3-dimethyl-2-aminobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.12
-
 (2RS)-5'-O-(3,3-dimethyl-2-oxobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.144
-
 (2RS)-5'-O-(3,3-dimethyl-2-hydroxy-4-methoxybutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.16
-
 (2RS)-5'-O-(3,3-dimethyl-2-aminobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 0.25
-
 (2RS)-5'-O-(3,3-dimethyl-2-aminobutyrylsulfamoyl)adenosine 25°C Escherichia coli
6.3.2.1 1.9
-
 3,3-dimethyl-2-oxobutyric acid 5-(6-aminopurin-9-yl)-3,4-dihydroxytetrahydrofuran-2-ylmethyl ester 25°C Escherichia coli
6.3.2.1 2.5
-
 (2RS)-adenosyl-2-hydroxy-3,3-dimethylbuyrate 25°C Escherichia coli
6.3.2.1 3.5
-
 (2RS)-adenosyl-2-hydroxy-4-methoxybutyrate 25°C Escherichia coli
6.3.2.1 9.5
-
 (2S)-adenosyl-2-L-amino-3,3-dimethylbutanoate 25°C Escherichia coli
6.3.2.1 18.2
-
 (2RS)-adenosyl-3,3-dimethyl-2-hydroxy-4-methoxybutyrate 25°C Escherichia coli