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Literature summary extracted from

  • Garcia-Molina, F.; Penalver, M.J.; Fenoll, L.G.; Rodriguez-Lopez, J.N.; Varon, R.; Gracia-Canovas, F.; Tudela, J.
    Kinetic study of monophenol and o-diphenol binding to oxytyrosinase (2005), J. Mol. Catal. B, 32, 185-192.
No PubMed abstract available

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.10.3.1 additional information
-
additional information detailed kinetics, overview Neurospora crassa
1.10.3.1 additional information
-
additional information detailed kinetics, overview Agaricus bisporus
1.10.3.1 additional information
-
additional information detailed kinetics, overview Streptomyces glaucescens
1.10.3.1 0.28
-
dopamine
-
Neurospora crassa
1.10.3.1 0.3
-
catechol
-
Agaricus bisporus
1.10.3.1 0.38
-
D-Dopa
-
Neurospora crassa
1.10.3.1 0.57
-
L-3,4-dihydroxyphenylalanine methyl ester
-
Agaricus bisporus
1.10.3.1 0.74
-
chlorogenic acid
-
Streptomyces glaucescens
1.10.3.1 0.8
-
L-Dopa
-
Agaricus bisporus
1.10.3.1 0.91
-
tert-butylcatechol
-
Streptomyces glaucescens
1.10.3.1 1.04
-
L-Dopa
-
Neurospora crassa
1.10.3.1 1.05
-
3,4-dihydroxyphenyl propionic acid
-
Streptomyces glaucescens
1.10.3.1 1.16
-
3,4-Dihydroxyphenyl acetic acid
-
Streptomyces glaucescens
1.10.3.1 1.89
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
1.10.3.1 1.9
-
4-methylcatechol
-
Streptomyces glaucescens
1.10.3.1 2.16
-
1,2,3-benzenetriol
-
Agaricus bisporus
1.10.3.1 2.2
-
dopamine
-
Agaricus bisporus
1.10.3.1 2.36
-
4-methylcatechol
-
Agaricus bisporus
1.10.3.1 2.8
-
tert-butylcatechol
-
Agaricus bisporus
1.10.3.1 4.4
-
3,4-Dihydroxyphenyl acetic acid
-
Neurospora crassa
1.10.3.1 4.5
-
catechol
-
Streptomyces glaucescens
1.10.3.1 4.5
-
D-Dopa
-
Agaricus bisporus
1.10.3.1 5.1
-
3,4-Dihydroxyphenyl acetic acid
-
Agaricus bisporus
1.10.3.1 5.77
-
L-Dopa
-
Streptomyces glaucescens
1.10.3.1 6.8
-
L-2-methyl-3,4-dihydroxyphenylalanine
-
Agaricus bisporus
1.10.3.1 7.1
-
L-isoproterenol
-
Agaricus bisporus
1.10.3.1 8
-
D-2-methyl-3,4-dihydroxyphenylalanine
-
Agaricus bisporus
1.10.3.1 11.9
-
dopamine
-
Streptomyces glaucescens
1.10.3.1 15.02
-
D-Dopa
-
Streptomyces glaucescens
1.10.3.1 18.1
-
D-isoproterenol
-
Agaricus bisporus
1.14.18.1 additional information
-
additional information detailed kinetics, overview Neurospora crassa
1.14.18.1 additional information
-
additional information detailed kinetics, overview Agaricus bisporus
1.14.18.1 additional information
-
additional information detailed kinetics, overview Streptomyces glaucescens
1.14.18.1 additional information
-
additional information detailed kinetics, overview Streptomyces antibioticus
1.14.18.1 0.08
-
4-methoxyphenol
-
Agaricus bisporus
1.14.18.1 0.17
-
4-ethoxyphenol
-
Agaricus bisporus
1.14.18.1 0.18
-
4-hydroxyphenyl acetic acid
-
Neurospora crassa
1.14.18.1 0.21
-
L-Tyr
-
Agaricus bisporus
1.14.18.1 0.32
-
D-Tyr
-
Neurospora crassa
1.14.18.1 0.38
-
L-tyrosine methyl ester
-
Agaricus bisporus
1.14.18.1 0.41
-
L-tyrosine
-
Streptomyces glaucescens
1.14.18.1 0.44
-
4-hydroxyphenyl propionic acid
-
Agaricus bisporus
1.14.18.1 0.48
-
4-hydroxyphenyl propionic acid
-
Streptomyces glaucescens
1.14.18.1 0.51
-
tyramine
-
Agaricus bisporus
1.14.18.1 0.59
-
L-Tyr
-
Neurospora crassa
1.14.18.1 0.67
-
tyramine
-
Neurospora crassa
1.14.18.1 0.7
-
phenol
-
Agaricus bisporus
1.14.18.1 1.1
-
4-Hydroxybenzyl alcohol
-
Agaricus bisporus
1.14.18.1 1.16
-
4-hydroxyphenyl acetic acid
-
Streptomyces glaucescens
1.14.18.1 1.2
-
DL-2-methyltyrosine
-
Agaricus bisporus
1.14.18.1 1.66
-
L-tyrosine methyl ester
-
Streptomyces glaucescens
1.14.18.1 1.86
-
D-Tyr
-
Agaricus bisporus
1.14.18.1 1.91
-
4-hydroxyphenyl acetic acid
-
Agaricus bisporus
1.14.18.1 2.9
-
4-Fluorophenol
-
Streptomyces antibioticus
1.14.18.1 5.4
-
3-methoxyphenol
-
Agaricus bisporus
1.14.18.1 6.9
-
3-Fluorophenol
-
Streptomyces antibioticus
1.14.18.1 10.1
-
3-Hydroxybenzyl alcohol
-
Agaricus bisporus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.10.3.1 Cu2+ copper enzyme Neurospora crassa
1.10.3.1 Cu2+ copper enzyme Agaricus bisporus
1.10.3.1 Cu2+ copper enzyme Streptomyces glaucescens

Organism

EC Number Organism UniProt Comment Textmining
1.10.3.1 Agaricus bisporus
-
-
-
1.10.3.1 Neurospora crassa
-
-
-
1.10.3.1 Streptomyces glaucescens
-
-
-
1.14.18.1 Agaricus bisporus
-
-
-
1.14.18.1 Neurospora crassa
-
-
-
1.14.18.1 Streptomyces antibioticus
-
-
-
1.14.18.1 Streptomyces glaucescens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.10.3.1 additional information
-
-
Neurospora crassa
1.10.3.1 additional information
-
-
Agaricus bisporus
1.10.3.1 additional information
-
-
Streptomyces glaucescens
1.14.18.1 additional information
-
-
Agaricus bisporus
1.14.18.1 additional information
-
-
Streptomyces glaucescens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.10.3.1 2 D-isoproterenol + O2
-
Agaricus bisporus 2 4-[(1S)-1-hydroxy-2-[(propan-2-yl)amino]ethyl]cyclohexa-3,5-diene-1,2-dione + 2 H2O
-
r
1.10.3.1 3,4-dihydroxyphenyl acetic acid + O2
-
Neurospora crassa ?
-
?
1.10.3.1 3,4-dihydroxyphenyl acetic acid + O2
-
Agaricus bisporus ?
-
?
1.10.3.1 3,4-dihydroxyphenyl acetic acid + O2
-
Streptomyces glaucescens ?
-
?
1.10.3.1 3,4-dihydroxyphenyl propionic acid + O2
-
Agaricus bisporus ?
-
r
1.10.3.1 3,4-dihydroxyphenyl propionic acid + O2
-
Streptomyces glaucescens ?
-
?
1.10.3.1 4-methylcatechol + O2
-
Agaricus bisporus 4-methyl-1,2-benzoquinone + H2O
-
?
1.10.3.1 4-methylcatechol + O2
-
Streptomyces glaucescens 4-methyl-1,2-benzoquinone + H2O
-
?
1.10.3.1 5-caffeoyl quinic acid + O2 i.e. chlorogenic acid Streptomyces glaucescens ?
-
?
1.10.3.1 catechol + 1/2 O2
-
Agaricus bisporus 1,2-benzoquinone + H2O
-
?
1.10.3.1 catechol + 1/2 O2
-
Streptomyces glaucescens 1,2-benzoquinone + H2O
-
?
1.10.3.1 chlorogenic acid + O2
-
Streptomyces glaucescens ?
-
?
1.10.3.1 D-2-methyl-3,4-dihydroxyphenylalanine + O2
-
Agaricus bisporus 2-methyldopaquinone + H2O
-
r
1.10.3.1 D-dopa + 1/2 O2
-
Neurospora crassa D-dopaquinone + H2O
-
?
1.10.3.1 D-dopa + 1/2 O2
-
Agaricus bisporus D-dopaquinone + H2O
-
?
1.10.3.1 D-dopa + 1/2 O2
-
Streptomyces glaucescens D-dopaquinone + H2O
-
?
1.10.3.1 D-isoproterenol + O2
-
Agaricus bisporus ?
-
?
1.10.3.1 DL-2-methyl-3,4-dihydroxyphenylalanine + O2 the L-isomer is preferred Agaricus bisporus 2-methyldopaquinone + H2O
-
?
1.10.3.1 DL-DOPA + O2 i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred Neurospora crassa dopaquinone + H2O
-
?
1.10.3.1 DL-DOPA + O2 i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred Agaricus bisporus dopaquinone + H2O
-
?
1.10.3.1 DL-DOPA + O2 i.e. DL-3,4-dihydroxyphenylalanine, the L-isomer is preferred Streptomyces glaucescens dopaquinone + H2O
-
?
1.10.3.1 DL-isoproterenol + O2 the L-isomer is preferred Agaricus bisporus ?
-
?
1.10.3.1 dopamine + O2
-
Neurospora crassa ?
-
?
1.10.3.1 dopamine + O2
-
Agaricus bisporus ?
-
?
1.10.3.1 dopamine + O2
-
Streptomyces glaucescens ?
-
?
1.10.3.1 L-2-methyl-3,4-dihydroxyphenylalanine + O2
-
Agaricus bisporus 2-methyldopaquinone + H2O
-
r
1.10.3.1 L-3,4-dihydroxyphenylalanine methyl ester + 1/2 O2
-
Agaricus bisporus L-dopaquinone methyl ester + H2O
-
?
1.10.3.1 L-tyrosine + L-dopa + O2
-
Neurospora crassa L-dopa + dopaquinone + H2O
-
?
1.10.3.1 L-tyrosine + L-dopa + O2
-
Streptomyces glaucescens L-dopa + dopaquinone + H2O
-
?
1.10.3.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Neurospora crassa ?
-
?
1.10.3.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Agaricus bisporus ?
-
?
1.10.3.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Streptomyces glaucescens ?
-
?
1.10.3.1 pyrogallol + O2
-
Agaricus bisporus ?
-
?
1.10.3.1 tert-butylcatechol + O2
-
Agaricus bisporus ?
-
?
1.10.3.1 tert-butylcatechol + O2
-
Streptomyces glaucescens ?
-
?
1.14.18.1 3-fluorophenol + O2
-
Streptomyces antibioticus ?
-
?
1.14.18.1 3-hydroxybenzyl alcohol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 3-methoxyphenol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 4-ethoxyphenol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 4-fluorophenol + O2
-
Streptomyces antibioticus ?
-
?
1.14.18.1 4-hydroxybenzyl alcohol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 4-hydroxyphenyl acetic acid + O2
-
Neurospora crassa ?
-
?
1.14.18.1 4-hydroxyphenyl acetic acid + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 4-hydroxyphenyl acetic acid + O2
-
Streptomyces glaucescens ?
-
?
1.14.18.1 4-hydroxyphenyl propionic acid + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 4-hydroxyphenyl propionic acid + O2
-
Streptomyces glaucescens ?
-
?
1.14.18.1 4-methoxyphenol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 D-tyrosine + L-dopa + O2
-
Neurospora crassa D-dopa + dopaquinone + H2O
-
?
1.14.18.1 D-tyrosine + L-dopa + O2
-
Agaricus bisporus D-dopa + dopaquinone + H2O
-
?
1.14.18.1 DL-2-methyltyrosine + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 L-tyrosine + L-dopa + O2
-
Neurospora crassa L-dopa + dopaquinone + H2O
-
?
1.14.18.1 L-tyrosine + L-dopa + O2
-
Agaricus bisporus L-dopa + dopaquinone + H2O
-
?
1.14.18.1 L-tyrosine + L-dopa + O2
-
Streptomyces glaucescens L-dopa + dopaquinone + H2O
-
?
1.14.18.1 L-tyrosine methyl ester + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 L-tyrosine methyl ester + O2
-
Streptomyces glaucescens ?
-
?
1.14.18.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Neurospora crassa ?
-
?
1.14.18.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Agaricus bisporus ?
-
?
1.14.18.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Streptomyces glaucescens ?
-
?
1.14.18.1 additional information the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview Streptomyces antibioticus ?
-
?
1.14.18.1 phenol + O2
-
Agaricus bisporus ?
-
?
1.14.18.1 tyramine + O2
-
Neurospora crassa ?
-
?
1.14.18.1 tyramine + O2
-
Agaricus bisporus ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.10.3.1 mettyrosinase
-
Neurospora crassa
1.10.3.1 mettyrosinase
-
Agaricus bisporus
1.10.3.1 mettyrosinase
-
Streptomyces glaucescens
1.10.3.1 More cf. 1.14.18.1 Neurospora crassa
1.10.3.1 More cf. 1.14.18.1 Agaricus bisporus
1.10.3.1 More cf. EC 1.14.18.1 Streptomyces glaucescens
1.10.3.1 o-diphenolase
-
Neurospora crassa
1.10.3.1 o-diphenolase
-
Agaricus bisporus
1.10.3.1 o-diphenolase
-
Streptomyces glaucescens
1.10.3.1 oxytyrosinase
-
Neurospora crassa
1.10.3.1 oxytyrosinase
-
Agaricus bisporus
1.10.3.1 oxytyrosinase
-
Streptomyces glaucescens
1.14.18.1 monophenolase
-
Neurospora crassa
1.14.18.1 monophenolase
-
Agaricus bisporus
1.14.18.1 monophenolase
-
Streptomyces glaucescens
1.14.18.1 monophenolase
-
Streptomyces antibioticus
1.14.18.1 More cf. EC 1.10.3.1 Neurospora crassa
1.14.18.1 More cf. EC 1.10.3.1 Agaricus bisporus
1.14.18.1 More cf. EC 1.10.3.1 Streptomyces glaucescens
1.14.18.1 More cf. EC 1.10.3.1 Streptomyces antibioticus
1.14.18.1 tyrosinase
-
Neurospora crassa
1.14.18.1 tyrosinase
-
Agaricus bisporus
1.14.18.1 tyrosinase
-
Streptomyces glaucescens
1.14.18.1 tyrosinase
-
Streptomyces antibioticus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.10.3.1 29.4
-
L-isoproterenol
-
Agaricus bisporus
1.10.3.1 29.8
-
D-isoproterenol
-
Agaricus bisporus
1.10.3.1 35.5
-
L-3,4-dihydroxyphenylalanine methyl ester
-
Agaricus bisporus
1.10.3.1 44.3
-
L-2-methyl-3,4-dihydroxyphenylalanine
-
Agaricus bisporus
1.10.3.1 44.3
-
D-2-methyl-3,4-dihydroxyphenylalanine
-
Agaricus bisporus
1.10.3.1 107.4
-
L-Dopa
-
Agaricus bisporus
1.10.3.1 107.4
-
D-Dopa
-
Agaricus bisporus
1.10.3.1 142
-
3,4-Dihydroxyphenyl acetic acid
-
Streptomyces glaucescens
1.10.3.1 184
-
D-Dopa
-
Streptomyces glaucescens
1.10.3.1 340
-
D-Dopa
-
Neurospora crassa
1.10.3.1 395
-
catechol
-
Streptomyces glaucescens
1.10.3.1 439
-
dopamine
-
Agaricus bisporus
1.10.3.1 533
-
3,4-Dihydroxyphenyl acetic acid
-
Agaricus bisporus
1.10.3.1 553.5
-
3,4-dihydroxyphenyl propionic acid
-
Agaricus bisporus
1.10.3.1 631.6
-
3,4-Dihydroxyphenyl acetic acid
-
Agaricus bisporus
1.10.3.1 641.8
-
tert-butylcatechol
-
Agaricus bisporus
1.10.3.1 785
-
chlorogenic acid
-
Streptomyces glaucescens
1.10.3.1 841.6
-
4-methylcatechol
-
Agaricus bisporus
1.10.3.1 850
-
3,4-Dihydroxyphenyl acetic acid
-
Neurospora crassa
1.10.3.1 875
-
dopamine
-
Streptomyces glaucescens
1.10.3.1 877.6
-
catechol
-
Agaricus bisporus
1.10.3.1 1070
-
L-Dopa
-
Neurospora crassa
1.10.3.1 1263
-
1,2,3-benzenetriol
-
Agaricus bisporus
1.10.3.1 1350
-
dopamine
-
Neurospora crassa
1.10.3.1 1445
-
L-Dopa
-
Streptomyces glaucescens
1.10.3.1 1830
-
3,4-dihydroxyphenyl propionic acid
-
Streptomyces glaucescens
1.10.3.1 2340
-
4-methylcatechol
-
Streptomyces glaucescens
1.10.3.1 3320
-
tert-butylcatechol
-
Streptomyces glaucescens
1.14.18.1 0.6
-
DL-2-methyltyrosine
-
Agaricus bisporus
1.14.18.1 3
-
3-Fluorophenol
-
Streptomyces antibioticus
1.14.18.1 3.4
-
L-tyrosine methyl ester
-
Agaricus bisporus
1.14.18.1 7.9
-
L-Tyr
-
Agaricus bisporus
1.14.18.1 8
-
D-Tyr
-
Agaricus bisporus
1.14.18.1 10.5
-
4-Fluorophenol
-
Streptomyces antibioticus
1.14.18.1 12.1
-
3-Hydroxybenzyl alcohol
-
Agaricus bisporus
1.14.18.1 12.7
-
phenol
-
Agaricus bisporus
1.14.18.1 13.2
-
L-tyrosine
-
Streptomyces glaucescens
1.14.18.1 20 50 4-Hydroxybenzyl alcohol
-
Agaricus bisporus
1.14.18.1 25.9
-
tyramine
-
Agaricus bisporus
1.14.18.1 44.3
-
4-hydroxyphenyl acetic acid
-
Agaricus bisporus
1.14.18.1 46.8
-
3-methoxyphenol
-
Agaricus bisporus
1.14.18.1 48.8
-
4-hydroxyphenyl acetic acid
-
Streptomyces glaucescens
1.14.18.1 66.7
-
4-hydroxyphenyl propionic acid
-
Agaricus bisporus
1.14.18.1 88.2
-
4-Hydroxybenzyl alcohol
-
Agaricus bisporus
1.14.18.1 132
-
4-ethoxyphenol
-
Agaricus bisporus
1.14.18.1 134
-
4-hydroxyphenyl propionic acid
-
Streptomyces glaucescens
1.14.18.1 160
-
tyramine
-
Neurospora crassa
1.14.18.1 160
-
D-Tyr
-
Neurospora crassa
1.14.18.1 184
-
4-methoxyphenol
-
Agaricus bisporus
1.14.18.1 235
-
L-tyrosine methyl ester
-
Streptomyces glaucescens
1.14.18.1 250
-
4-hydroxyphenyl acetic acid
-
Neurospora crassa
1.14.18.1 320
-
L-Tyr
-
Neurospora crassa