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Literature summary extracted from
- Direct evidence for a glutamate switch necessary for substrate recognition: crystal structures of lysine epsilon-aminotransferase (Rv3290c) from Mycobacterium tuberculosis H37Rv (2006), J. Mol. Biol., 362, 877-886.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 2.6.1.36 | - |
Mycobacterium tuberculosis |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.6.1.36 | 1.2 | - |
L-lysine | - |
Mycobacterium tuberculosis |  |
| 2.6.1.36 | 2.3 | - |
2-oxoglutarate | - |
Mycobacterium tuberculosis | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 2.6.1.36 | 50000 | - |
SDS-PAGE | Mycobacterium tuberculosis |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.6.1.36 | Mycobacterium tuberculosis | P9WQ77 | - |
- |
| 2.6.1.36 | Mycobacterium tuberculosis H37Rv | P9WQ77 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.6.1.36 | - |
Mycobacterium tuberculosis |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.6.1.36 | L-lysine + 2-oxoglutarate | - |
Mycobacterium tuberculosis | 2-aminoadipate 6-semialdehyde + L-glutamate | - |
r | |
| 2.6.1.36 | L-lysine + 2-oxoglutarate | - |
Mycobacterium tuberculosis H37Rv | 2-aminoadipate 6-semialdehyde + L-glutamate | - |
r | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 2.6.1.36 | dimer | gel filtration | Mycobacterium tuberculosis |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.6.1.36 | LAT | - |
Mycobacterium tuberculosis |
| 2.6.1.36 | lysine epsilon-aminotransferase | - |
Mycobacterium tuberculosis |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 2.6.1.36 | 0.917 | - |
L-lysine | - |
Mycobacterium tuberculosis | |
| 2.6.1.36 | 1.43 | - |
2-oxoglutarate | - |
Mycobacterium tuberculosis | |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.6.1.36 | pyridoxal 5'-phosphate | dependent | Mycobacterium tuberculosis | |
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