EC Number | Application | Comment | Organism |
---|---|---|---|
2.1.1.5 | analysis | synthesis of a series of S-substituted derivatives of homocysteine as potential inhibitors of human recombinant BHMT, some of these compounds are very potent inhibitors, having IC50 values in the nanomolar range | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.1.1.5 | (R,S)-2-(3-amino-3-carboxy-propylsulfanyl)-benzoic acid | ca. 43% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(2-carboxy-ethyldisulfanyl)-butyric acid | ca. 30% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(2-carboxymethylsulfanyl-ethylsulfanyl)-butyric acid | 100% inhibition at 0.02 mM, very potent inhibitor and one of the strongest ever reported | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(2-carboxymethylsulfinyl-ethylsulfanyl)-butyric acid | ca. 90% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(2-phosphonomethoxy-ethylsulfanyl)-butyrate | ca. 26% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(3-carboxy-propylsulfanyl)-butyric acid | ca. 20% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(4-carboxymethyl-benzylsulfanyl)-butyric acid | ca. 10% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-(4-phosphono-butylsulfanyl)-butyric acid | ca. 98% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-methylsulfanylmethylsulfanyl-butyric acid | ca. 21% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-2-amino-4-[(phosphonomethyl-carbamoyl)-methylsulfanyl]-butyrate | ca. 9% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-3-(3-amino-3-carboxy-propylsulfanyl)-benzoic acid | ca. 13% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-4-(3-amino-3-carboxy-propylsulfanyl)-benzoic acid | ca. 99% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentanoic acid | 100% inhibition at 0.02 mM, very potent inhibitor and one of the strongest ever reported, competitive inhibition with respect to betaine binding | Homo sapiens | |
2.1.1.5 | (R,S)-5-(3-amino-3-carboxy-propylsulfinyl)-pentanoic acid | ca. 97% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-5-(3-amino-3-carboxy-propylsulfonyl)-pentanoic acid | ca. 29% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | (R,S)-6-(3-amino-3-carboxy-propylsulfanyl)-hexanoic acid | 100% inhibition at 0.02 mM, very potent inhibitor and one of the strongest ever reported | Homo sapiens | |
2.1.1.5 | (R,S,R,S)-2-amino-4-(2-amino-2-carboxy-ethylsulfinyl)-butyric acid | ca. 10% inhibition at 0.02 mM | Homo sapiens | |
2.1.1.5 | additional information | not inhibited by (R)-5-(2-amino-2-carboxy-ethylsulfanyl)-pentanoic acid, (R,S)-4-allylsulfanyl-2-amino-butyric acid and (R,S)-2-amino-4-[(phosphonomethyl-carbamoyl)-methylsulfanyl]-butyric acid ester | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.5 | 0.008 | - |
DL-homocysteine | - |
Homo sapiens | |
2.1.1.5 | 2 | - |
betaine | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.1.1.5 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.1.1.5 | betaine + DL-homocysteine | - |
Homo sapiens | dimethylglycine + L-methionine | - |
r | |
2.1.1.5 | L-homocysteine + betaine | - |
Homo sapiens | L-methionine + dimethylglycine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.1.1.5 | BHMT | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.1.1.5 | 0.000012 | - |
(R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentanoic acid | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.1.1.5 | 0.000087 | - |
- |
Homo sapiens | (R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentanoic acid | |
2.1.1.5 | 0.000096 | - |
- |
Homo sapiens | (R,S)-2-amino-4-(2-carboxymethylsulfanyl-ethylsulfanyl)-butyric acid | |
2.1.1.5 | 0.0002 | - |
- |
Homo sapiens | (R,S)-6-(3-amino-3-carboxy-propylsulfanyl)-hexanoic acid | |
2.1.1.5 | 0.005 | - |
- |
Homo sapiens | (R,S)-5-(3-amino-3-carboxy-propylsulfinyl)-pentanoic acid | |
2.1.1.5 | 0.0057 | - |
- |
Homo sapiens | (R,S)-2-amino-4-(4-phosphono-butylsulfanyl)-butyric acid | |
2.1.1.5 | 0.007 | - |
- |
Homo sapiens | (R,S)-4-(3-amino-3-carboxy-propylsulfanyl)-benzoic acid |