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Literature summary extracted from

  • Liu, K.H.; Kim, M.J.; Jeon, B.H.; Shon, J.H.; Cha, I.J.; Cho, K.H.; Lee, S.S.; Shin, J.G.
    Inhibition of human cytochrome P450 isoforms and NADPH-CYP reductase in vitro by 15 herbal medicines, including Epimedii herba (2006), J. Clin. Pharm. Ther., 31, 83-91.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 additional information the herbal medicines Epimedii herba, Glycyrrhizae radix and Leonuri herba inhibit one or more NADPH-CYP reductase. Epimedii herba extract is the most potent inhibitor, IC50: 0.1859 mg/ml Homo sapiens
1.6.2.4 quercetin IC50: 0.00088 mg/ml Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 microsome
-
 Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADPH
-
 Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.6.2.4 NADPH-CYP reductase
-
 Homo sapiens