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Literature summary extracted from

  • Li, B.H.; Ma, X.F.; Wang, Y.; Tian, W.X.
    Structure-activity relationship of polyphenols that inhibit fatty acid synthase (2005), J. Biochem., 138, 679-685.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.85 4',6,7-trihydroxylisoflavone IC50: 0.0295 mM Anas platyrhynchos
2.3.1.85 apigenin IC50: 0.0176 mM Anas platyrhynchos
2.3.1.85 daidzein IC50: 0.0732 mM Anas platyrhynchos
2.3.1.85 genistein 0.0287 mM Anas platyrhynchos
2.3.1.85 iso-liquiritigenin IC50: 0.0088 mM Anas platyrhynchos
2.3.1.85 additional information a common model is proposed that is possibly shared by all FAS polyphenol inhibitors. The model includes two almost planar aromatic rings with their respective hydroxyl groups, and a proper ester linkage between the two rings that possibly causes the inhibition of FAS by irreversibly inhibiting the beta-ketoacyl reductase domain Anas platyrhynchos
2.3.1.85 nordihydroguaiaretic acid inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM Anas platyrhynchos
2.3.1.85 phloretin 0.0261 mM Anas platyrhynchos
2.3.1.85 resveratrol IC50: 0.0085 mM Anas platyrhynchos

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.85 Anas platyrhynchos
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.85 acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
Anas platyrhynchos palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
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IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.3.1.85 0.0085
-
IC50: 0.0085 mM Anas platyrhynchos resveratrol
2.3.1.85 0.0088
-
IC50: 0.0088 mM Anas platyrhynchos iso-liquiritigenin
2.3.1.85 0.0176
-
IC50: 0.0176 mM Anas platyrhynchos apigenin
2.3.1.85 0.0295
-
IC50: 0.0295 mM Anas platyrhynchos 4',6,7-trihydroxylisoflavone
2.3.1.85 0.0732
-
IC50: 0.0732 mM Anas platyrhynchos daidzein
2.3.1.85 0.093
-
inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM Anas platyrhynchos nordihydroguaiaretic acid