EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.3.1.85 | 4',6,7-trihydroxylisoflavone | IC50: 0.0295 mM | Anas platyrhynchos | |
2.3.1.85 | apigenin | IC50: 0.0176 mM | Anas platyrhynchos | |
2.3.1.85 | daidzein | IC50: 0.0732 mM | Anas platyrhynchos | |
2.3.1.85 | genistein | 0.0287 mM | Anas platyrhynchos | |
2.3.1.85 | iso-liquiritigenin | IC50: 0.0088 mM | Anas platyrhynchos | |
2.3.1.85 | additional information | a common model is proposed that is possibly shared by all FAS polyphenol inhibitors. The model includes two almost planar aromatic rings with their respective hydroxyl groups, and a proper ester linkage between the two rings that possibly causes the inhibition of FAS by irreversibly inhibiting the beta-ketoacyl reductase domain | Anas platyrhynchos | |
2.3.1.85 | nordihydroguaiaretic acid | inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM | Anas platyrhynchos | |
2.3.1.85 | phloretin | 0.0261 mM | Anas platyrhynchos | |
2.3.1.85 | resveratrol | IC50: 0.0085 mM | Anas platyrhynchos |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.3.1.85 | Anas platyrhynchos | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.3.1.85 | acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ | - |
Anas platyrhynchos | palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O | - |
? |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.3.1.85 | 0.0085 | - |
IC50: 0.0085 mM | Anas platyrhynchos | resveratrol | |
2.3.1.85 | 0.0088 | - |
IC50: 0.0088 mM | Anas platyrhynchos | iso-liquiritigenin | |
2.3.1.85 | 0.0176 | - |
IC50: 0.0176 mM | Anas platyrhynchos | apigenin | |
2.3.1.85 | 0.0295 | - |
IC50: 0.0295 mM | Anas platyrhynchos | 4',6,7-trihydroxylisoflavone | |
2.3.1.85 | 0.0732 | - |
IC50: 0.0732 mM | Anas platyrhynchos | daidzein | |
2.3.1.85 | 0.093 | - |
inhibits competitively with respect to acetyl-CoA, noncompetitively with respect to malonyl-CoA, and in a mixed manner with respect toNADPH.IC50 = 0.093 mM | Anas platyrhynchos | nordihydroguaiaretic acid |