Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Tsuchida, A.; Ogiso, M.; Nakamura, Y.; Kiso, M.; Furukawa, K.; Furukawa, K.
    Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity (2005), J. Biochem., 138, 237-243.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.7 short and long enzyme form of 305 and 240 amino acids, respectively, DNA and amino acid sequence determination and analysis, alternative usage of the second exon seems to generate these two transcripts, expression analysis, sequence comparisons, overview, expression of soluble fusion enzyme, a truncated form of ST6GalNAc III lacking 21 amino acids from the NH2 terminus Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.7 membrane type II membrane protein Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.3.7 Mg2+
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.7 brain
-
 Homo sapiens
-
2.4.3.7 kidney
-
 Homo sapiens
-
2.4.3.7 additional information tissue distribution of isozyme expression Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.7 CMP-Neu5Ac + fetuin ST6GalNAc III also shows activity with O-glycans, but not N-glycans, in fetuin Homo sapiens ?
-
 ?
2.4.3.7 CMP-Neu5Ac + Galbeta1,3GlcNAcbeta1,3Galbeta1,4Glcbeta1-Cer
-
 Homo sapiens ?
-
 ?
2.4.3.7 CMP-Neu5Ac + Galbeta1,4GlcNAcbeta1,3Galbeta1,4Glcbeta1-Cer
-
 Homo sapiens ?
-
 ?
2.4.3.7 CMP-Neu5Ac + GM1b i.e. NeuAcalpha2,3Galbeta1,3GalNAcbeta1,4Galbeta1,4Glcbeta1-Cer, best substrate Homo sapiens ?
-
 ?
2.4.3.7 additional information substrate specificity, no activity with GA1, GA2, GM1, GM2, GD3, GT1b, GQ1b, and Lc4, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.3.7 More two transmembrane isozymes, short and long enzyme form of 305 and 240 amino acids, respectively, the long form shows a short cytoplasmic transmembrane domain of sixteen amino acids and a catalytic domain of 280 amino acids, both isozymes contain the sialyl motif L and sialyl motif S, overview Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.3.7 ST6GalNAc III
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.7 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.7 6
-
 assay at Homo sapiens