Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Levin, I.; Mevarech, M.; Palfey, B.A.
    Characterization of a novel bifunctional dihydropteroate synthase/dihydropteroate reductase enzyme from Helicobacter pylori (2007), J. Bacteriol., 189, 4062-4069.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.15 expression in Escherichia coli Helicobacter pylori

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.15 G58A site-directed mutagenesis, cannot replace DHPR in Escherichia coli, affects the binding affinity for FMN Helicobacter pylori
2.5.1.15 K31A site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN Helicobacter pylori
2.5.1.15 K51A site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN Helicobacter pylori
2.5.1.15 K92E site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN Helicobacter pylori
2.5.1.15 M28E site-directed mutagenesis, can replace DHPR in Escherichia coli, affects the binding affinity for FMN Helicobacter pylori
2.5.1.15 additional information DHPS contains also dihydropteroate reductase activity Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Helicobacter pylori
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Helicobacter pylori Q49HL6
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Helicobacter pylori diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
 Helicobacter pylori
2.5.1.15 DHPS
-
 Helicobacter pylori
2.5.1.15 DHPS/DHPR
-
 Helicobacter pylori
2.5.1.15 dihydropteroate synthase
-
 Helicobacter pylori
2.5.1.15 FolP
-
 Helicobacter pylori

Cofactor

EC Number Cofactor Comment Organism Structure
2.5.1.15 flavin adenine dinucleotide
-
 Helicobacter pylori
2.5.1.15 FMN
-
 Helicobacter pylori