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Literature summary extracted from

  • Giroix, M.H.; Jijakli, H.; Courtois, P.; Zhang, Y.; Sener, A.; Malaisse, W.J.
    Fructokinase activity in rat liver, ileum, parotid gland, pancreas, pancreatic islet, B and non-B islet cell homogenates (2006), Int. J. Mol. Med., 17, 517-522.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.3 additional information the phosphorylation of D-fructose by ketohexokinase is resistant to inhibition by D-mannoheptulose Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.3 Rattus norvegicus
-
 adult albino Wistar rats of both sexes
-
2.7.1.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.3 ileum 12.4% of the phosphorylation of D-fructose by ileum homogenates is attributable to ketohexokinase Rattus norvegicus
-
2.7.1.3 liver the phosphorylation of D-fructose by liver homogenates is attributable to ketohexokinase Rattus norvegicus
-
2.7.1.3 additional information there is no biologically significant amount of ketohexokinase in the parotid gland Rattus norvegicus
-
2.7.1.3 additional information semi-purified B and non-B islet cells are investigated. The major fraction of D-fructose phosphorylation by islet cell homogenates (B and non-B) is not attributable to ketohexokinase. Rattus norvegicus
-
2.7.1.3 pancreas activity of ketohexokinase in pancreas homogenates. In pancreatic islets ketohexokinase activity is present. Rattus norvegicus
-
2.7.1.4 ileum
-
 Rattus norvegicus
-
2.7.1.4 liver
-
 Rattus norvegicus
-
2.7.1.4 pancreas
-
 Rattus norvegicus
-
2.7.1.4 pancreatic beta cell
-
 Rattus norvegicus
-
2.7.1.4 pancreatic islet
-
 Rattus norvegicus
-
2.7.1.4 parotid gland
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.7.1.3 0.00014
-
 in B and non-B cells. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus
2.7.1.3 0.000158
-
 in parotid gland. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus
2.7.1.3 0.00046
-
 in islets. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus
2.7.1.3 0.00082
-
 in pancreas. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus
2.7.1.3 0.00245
-
 in ileum. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus
2.7.1.3 0.02154
-
 in liver. The reaction velocity is recorded in the presence of D-fructose (1.0 mM) and K+ in heated homogenate, it is expressed relative to protein content. Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.4 ATP + D-fructose
-
 Rattus norvegicus ADP + D-fructose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.3 fructokinase ketohexokinase Rattus norvegicus
2.7.1.4 FRK
-
 Rattus norvegicus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
2.7.1.3 70
-
 heat resistant Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.4 ATP
-
 Rattus norvegicus