EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.15 | UDP-alpha-D-glucose + D-glucose 6-phosphate | Cryptococcus neoformans var. grubii | both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target | UDP + alpha,alpha-trehalose 6-phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.15 | Cryptococcus neoformans var. grubii | Q6IVK9 | - |
- |
3.1.3.12 | Cryptococcus neoformans | Q059G6 | - |
- |
3.1.3.12 | Cryptococcus neoformans H99 | Q059G6 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.15 | UDP-alpha-D-glucose + D-glucose 6-phosphate | - |
Cryptococcus neoformans var. grubii | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
2.4.1.15 | UDP-alpha-D-glucose + D-glucose 6-phosphate | both TPS1 and TPS2 are required for high-temperature (37°C) growth and glycolysis but that the block at TPS2 results in the apparent toxic accumulation of trehalose-6-phosphate, which makes this enzyme a fungicidal target | Cryptococcus neoformans var. grubii | UDP + alpha,alpha-trehalose 6-phosphate | - |
? | |
3.1.3.12 | trehalose 6-phosphate + H2O | - |
Cryptococcus neoformans | trehalose + phosphate | - |
? | |
3.1.3.12 | trehalose 6-phosphate + H2O | - |
Cryptococcus neoformans H99 | trehalose + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.15 | TPS1 | - |
Cryptococcus neoformans var. grubii |
3.1.3.12 | T6P phosphatase | - |
Cryptococcus neoformans |
3.1.3.12 | TPS2 | - |
Cryptococcus neoformans |
3.1.3.12 | trehalose-6-phosphate phosphatase | - |
Cryptococcus neoformans |