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Literature summary extracted from

  • Kim, M.Y.; Zhang, T.; Kraus, W.L.
    Poly(ADP-ribosyl)ation by PARP-1: PAR-laying NAD+ into a nuclear signal (2005), Genes Dev., 19, 1951-1967.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30 trancriptional regulation, overview Drosophila melanogaster
2.4.2.30 trancriptional regulation, overview Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.30 additional information phenotypes of isozyme-deficient mutant mice, overview Drosophila melanogaster
2.4.2.30 additional information phenotypes of isozyme-deficient mutant mice, overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.2.30 nucleus
-
 Drosophila melanogaster 5634
-
2.4.2.30 nucleus
-
 Mus musculus 5634
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.2.30 additional information Drosophila melanogaster transcriptional regulation mechanism, overview ?
-
 ?
2.4.2.30 additional information Mus musculus transcriptional regulation mechanism, overview ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Drosophila melanogaster poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor Mus musculus poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Drosophila melanogaster
-
-
-
2.4.2.30 Mus musculus
-
 isozymes PARP-1 and PARP-2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 additional information transcriptional regulation mechanism, overview Drosophila melanogaster ?
-
 ?
2.4.2.30 additional information transcriptional regulation mechanism, overview Mus musculus ?
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR Drosophila melanogaster nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor poly(ADP-ribosyl)ation, i.e. PARylation, plays diverse roles in many molecular and cellular processes, including DNA damage detection and repair, chromatin modification, transcription, cell death pathways, insulator function, and mitotic apparatus function, connections between nuclear NAD+ metabolism and nuclear signaling through PARP-1, physiologic functions, detailed overview, synthesis and degradation of PAR on an acceptor protein, pathway overview, the enzyme is involved in regulation of the steady-state levels of PAR Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor linking a long negatively charged polymer to a protein, PARP catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview Drosophila melanogaster nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor linking a long negatively charged polymer to a protein, PARP-1 catalyzes the polymerization of ADP-ribose units from donor NAD+ molecules on target proteins, resulting in the attachment of PAR, each residue in PAR contains an adenine moiety capable of base stacking and hydrogen bonding, as well as two phosphate groups that carry negative charges, substrate structure, overview Mus musculus nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.2.30 More structural and functional organizations of PARP-1 and PARP-2, overview Mus musculus

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 PAR polymerase
-
 Drosophila melanogaster
2.4.2.30 PAR polymerase
-
 Mus musculus
2.4.2.30 PARP
-
 Drosophila melanogaster
2.4.2.30 PARP
-
 Mus musculus