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Literature summary extracted from

  • Witte, A.B.; Anestal, K.; Jerremalm, E.; Ehrsson, H.; Arner, E.S.
    Inhibition of thioredoxin reductase but not of glutathione reductase by the major classes of alkylating and platinum-containing anticancer compounds (2005), Free Radic. Biol. Med., 39, 696-703.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 cisplatin 0.01-0.2 mM Saccharomyces cerevisiae
1.8.1.7 monohydrated complex of cisplatin 0.01-0.2 mM Saccharomyces cerevisiae
1.8.1.7 additional information no inhibition by chlorambucil, melphalan, busulfan and carboplatin Saccharomyces cerevisiae
1.8.1.7 oxaliplatin 0.01-0.2 mM Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Saccharomyces cerevisiae glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Saccharomyces cerevisiae
1.8.1.7 GR
-
 Saccharomyces cerevisiae