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Literature summary extracted from

  • Sohn, H.; Kim, Y.; Kim, H.; Kim, C.; Cho, E.; Kang, H.; Kim, N.; Kim, C.; Ryu, S.E.; Lee, J.; Ko, J.H.
    Ganglioside GM3 is involved in neuronal cell death (2006), FASEB J., 20, 1248-1250.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.3.9 additional information GM3 is up-regulated in glutamate-induced neuronal cell death Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.9 functional expression in HT22 cells, GM3 levels are increased in immortalized mouse hippocampal HT22 cells after exposure to glutamate, GM3 not only mediates the effect of glutamate on the oxidative death of HT22 cells but also acts, in itself, as a modulator of in vivo neuronal cell death, overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide Mus musculus ganglioside GM3 is involved in neuronal cell death CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
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 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.9 Mus musculus O88829
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.9 brain
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide
-
 Mus musculus CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide ganglioside GM3 is involved in neuronal cell death Mus musculus CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.9 GM3 synthase
-
 Mus musculus
2.4.3.9 ST3GalV
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 Mus musculus