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Literature summary extracted from

  • Estey, T.; Piatigorsky, J.; Lassen, N.; Vasiliou, V.
    ALDH3A1: a corneal crystallin with diverse functions (2007), Exp. Eye Res., 84, 3-12.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.2.1.4 medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Mammalia
1.2.1.4 medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Mus musculus
1.2.1.4 medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Homo sapiens
1.2.1.4 medicine ALDH3A1 contributes to the detoxification of various aldehydes produced in response to oxidative stress Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.4 additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Homo sapiens
1.2.1.4 additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Mammalia
1.2.1.4 additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Mus musculus
1.2.1.4 additional information ALDH3A1 is inactivated and covalently cross-linked by direct UV-exposure Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.2.1.4 0.012
-
 trans-2-nonenal purified ALDH3A1 Mammalia
1.2.1.4 0.012
-
 trans-2-nonenal purified ALDH3A1 Mus musculus
1.2.1.4 0.012
-
 trans-2-nonenal purified ALDH3A1 Homo sapiens
1.2.1.4 0.012
-
 trans-2-nonenal purified ALDH3A1 Oryctolagus cuniculus
1.2.1.4 0.035
-
 trans-2-octenal purified ALDH3A1 Mammalia
1.2.1.4 0.035
-
 trans-2-octenal purified ALDH3A1 Mus musculus
1.2.1.4 0.035
-
 trans-2-octenal purified ALDH3A1 Homo sapiens
1.2.1.4 0.035
-
 trans-2-octenal purified ALDH3A1 Oryctolagus cuniculus
1.2.1.4 0.045
-
 4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Mammalia
1.2.1.4 0.045
-
 4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Mus musculus
1.2.1.4 0.045
-
 4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Homo sapiens
1.2.1.4 0.045
-
 4-hydroxy-2-nonenal purified recombinant human ALDH3A1 Oryctolagus cuniculus
1.2.1.4 0.056
-
 4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Mammalia
1.2.1.4 0.056
-
 4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Mus musculus
1.2.1.4 0.056
-
 4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Homo sapiens
1.2.1.4 0.056
-
 4-hydroxy-2-nonenal in the cytosolic extracts of the ALDH3A1-transfected HCE cells Oryctolagus cuniculus
1.2.1.4 0.155
-
 trans-2-hexenal purified ALDH3A1 Mammalia
1.2.1.4 0.155
-
 trans-2-hexenal purified ALDH3A1 Mus musculus
1.2.1.4 0.155
-
 trans-2-hexenal purified ALDH3A1 Homo sapiens
1.2.1.4 0.155
-
 trans-2-hexenal purified ALDH3A1 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.4 cytosol
-
 Mammalia 5829
-
1.2.1.4 cytosol
-
 Mus musculus 5829
-
1.2.1.4 cytosol
-
 Homo sapiens 5829
-
1.2.1.4 cytosol
-
 Oryctolagus cuniculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.2.1.4 an aldehyde + NADP+ + H2O Mammalia
-
 an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O Mus musculus
-
 an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O Homo sapiens
-
 an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O Oryctolagus cuniculus
-
 an acid + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.4 Homo sapiens
-
-
-
1.2.1.4 Mammalia
-
-
-
1.2.1.4 Mus musculus
-
-
-
1.2.1.4 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.1.4 cornea
-
 Mammalia
-
1.2.1.4 HCE cell
-
 Homo sapiens
-
1.2.1.4 NCTC 2544 cell skin keratinocyte Homo sapiens
-
1.2.1.4 RAW-264.7 cell murine macrophages Mus musculus
-
1.2.1.4 TRK-43 cell cultured rabbit stromal fibroblasts Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.4 4-hydroxy-2-nonenal + NADP+ + H2O
-
 Mammalia (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
 ?
1.2.1.4 4-hydroxy-2-nonenal + NADP+ + H2O
-
 Mus musculus (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
 ?
1.2.1.4 4-hydroxy-2-nonenal + NADP+ + H2O
-
 Homo sapiens (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
 ?
1.2.1.4 4-hydroxy-2-nonenal + NADP+ + H2O
-
 Oryctolagus cuniculus (2E)-4-hydroxynon-2-enoate + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O
-
 Mammalia an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O
-
 Mus musculus an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O
-
 Homo sapiens an acid + NADPH + H+
-
 ?
1.2.1.4 an aldehyde + NADP+ + H2O
-
 Oryctolagus cuniculus an acid + NADPH + H+
-
 ?
1.2.1.4 trans-2-hexenal + NADP+ + H2O
-
 Mammalia (2E)-hex-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-hexenal + NADP+ + H2O
-
 Mus musculus (2E)-hex-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-hexenal + NADP+ + H2O
-
 Homo sapiens (2E)-hex-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-hexenal + NADP+ + H2O
-
 Oryctolagus cuniculus (2E)-hex-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-nonenal + NADP+ + H2O
-
 Mammalia (2E)-non-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-nonenal + NADP+ + H2O
-
 Mus musculus (2E)-non-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-nonenal + NADP+ + H2O
-
 Homo sapiens (2E)-non-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-nonenal + NADP+ + H2O
-
 Oryctolagus cuniculus (2E)-non-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-octenal + NADP+ + H2O
-
 Mammalia (2E)-oct-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-octenal + NADP+ + H2O
-
 Mus musculus (2E)-oct-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-octenal + NADP+ + H2O
-
 Homo sapiens (2E)-oct-2-enoate + NADPH + H+
-
 ?
1.2.1.4 trans-2-octenal + NADP+ + H2O
-
 Oryctolagus cuniculus (2E)-oct-2-enoate + NADPH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.4 aldehyde dehydrogenase (NADP+)
-
 Mammalia
1.2.1.4 aldehyde dehydrogenase (NADP+)
-
 Mus musculus
1.2.1.4 aldehyde dehydrogenase (NADP+)
-
 Homo sapiens
1.2.1.4 aldehyde dehydrogenase (NADP+)
-
 Oryctolagus cuniculus
1.2.1.4 aldehyde dehydrogenase 3A1
-
 Mammalia
1.2.1.4 aldehyde dehydrogenase 3A1
-
 Mus musculus
1.2.1.4 aldehyde dehydrogenase 3A1
-
 Homo sapiens
1.2.1.4 aldehyde dehydrogenase 3A1
-
 Oryctolagus cuniculus
1.2.1.4 ALDH3A1
-
 Mammalia
1.2.1.4 ALDH3A1
-
 Mus musculus
1.2.1.4 ALDH3A1
-
 Homo sapiens
1.2.1.4 ALDH3A1
-
 Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.2.1.4 NADPH
-
 Mammalia
1.2.1.4 NADPH
-
 Mus musculus
1.2.1.4 NADPH
-
 Homo sapiens
1.2.1.4 NADPH
-
 Oryctolagus cuniculus