Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Erdogan, O.; Hisar, O.; Koeroglu, G.; Ciltas, A.
    Sublethal ammonia and urea concentrations inhibit rainbow trout (Oncorhynchus mykiss) erythrocyte glucose 6-phosphate dehydrogenase (2005), Comp. Biochem. Physiol. C, 141C, 145-150.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.49 ammonia inhibition in vitro and in vivo at sublethal concentration of 0.0022-0.0055 mM, IC50: 0.0187 mM Oncorhynchus mykiss
1.1.1.49 Urea inhibition in vitro and in vivo at sublethal concentration of 0.02-0.05 mM, IC50: 0.0238 mM Oncorhynchus mykiss

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.49 Oncorhynchus mykiss
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.49 native enzyme 1600fold from erythrocytes by ammonium sulfate fractionation, and 2',5'-ADP affinity chromatography to homogeneity Oncorhynchus mykiss

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.49 erythrocyte
-
 Oncorhynchus mykiss
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.49 16.7
-
 purified enzyme Oncorhynchus mykiss

Synonyms

EC Number Synonyms Comment Organism
1.1.1.49 G6PD
-
 Oncorhynchus mykiss
1.1.1.49 glucose 6-phosphate dehydrogenase
-
 Oncorhynchus mykiss

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.49 0.00186
-
 Urea
-
 Oncorhynchus mykiss
1.1.1.49 0.00226
-
 ammonia
-
 Oncorhynchus mykiss

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.1.1.49 0.0187
-
 inhibition in vitro and in vivo at sublethal concentration of 0.0022-0.0055 mM, IC50: 0.0187 mM Oncorhynchus mykiss ammonia
1.1.1.49 0.0238
-
 inhibition in vitro and in vivo at sublethal concentration of 0.02-0.05 mM, IC50: 0.0238 mM Oncorhynchus mykiss Urea