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Literature summary extracted from

  • Saieed, P.; Reza, R.M.; Abbas, D.; Seyyedvali, R.; Aliasghar, H.
    Inhibitory effects of Ruta graveolens L. extract on guinea pig liver aldehyde oxidase. [Erratum to document cited in CA144:381924] (2006), Chem. Pharm. Bull., 54, 925.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.3.1 allopurinol at 0.01 mM, 13% inhibition of 0.1 mM substrate benzaldehyde, 6% inhibition of 0.05 mM substrate phenanthridine, 7% inhibition of 0.05 mM substrate vanillin Cavia porcellus
1.2.3.1 menadione at 0.01 mM, 80% inhibition of 0.1 mM substrate benzaldehyde, 96% inhibition of 0.05 mM substrate phenanthridine, 89% inhibition of 0.05 mM substrate vanillin Cavia porcellus
1.2.3.1 quercetin at 0.01 mM, 96% inhibition of 0.1 mM substrate benzaldehyde, 69% inhibition of 0.05 mM substrate phenanthridine, 91% inhibition of 0.05 mM substrate vanillin. Mixed type inhibition for all three substrates Cavia porcellus
1.2.3.1 rutin at 0.01 mM, 52% inhibition of 0.1 mM substrate benzaldehyde, 27% inhibition of 0.05 mM substrate phenanthridine, 34% inhibition of 0.05 mM substrate vanillin. Mixed type inhibition for benzaldehyde and vanillin, non-competitive with phenanthridine Cavia porcellus

Organism

EC Number Organism UniProt Comment Textmining
1.2.3.1 Cavia porcellus
-
 male
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.2.3.1 liver partial purification of enzyme Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.3.1 benzaldehyde + H2O + O2
-
 Cavia porcellus benzoic acid + H2O2
-
 ?
1.2.3.1 phenanthridine + H2O + O2
-
 Cavia porcellus 6-phenantridone + H2O2
-
 ?
1.2.3.1 vanillin + H2O + O2
-
 Cavia porcellus vanillic acid + H2O2
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2.3.1 0.0004
-
 quercetin pH 7.0, 37°C, substrate benzaldehyde Cavia porcellus
1.2.3.1 0.0005
-
 quercetin pH 7.0, 37°C, substrate vanillin Cavia porcellus
1.2.3.1 0.00092
-
 rutin pH 7.0, 37°C, substrate vanillin Cavia porcellus
1.2.3.1 0.001
-
 rutin pH 7.0, 37°C, substrate benzaldehyde Cavia porcellus
1.2.3.1 0.0017
-
 quercetin pH 7.0, 37°C, substrate phenanthridine Cavia porcellus