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Literature summary extracted from

  • Zhang, X.; Beaulieu, J.M.; Gainetdinov, R.R.; Caron, M.G.
    Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2 (2006), Cell. Mol. Life Sci., 63, 6-11.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Gallus gallus
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Drosophila melanogaster
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Mus musculus
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Rattus norvegicus
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Danio rerio
-
 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 Homo sapiens over 300 single nucleotide polymorphisms have been identified and are associated with symptoms ranging from mild hyperphenylalaninemia to severe phenylketonuria 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.16.4 Danio rerio
-
-
-
1.14.16.4 Drosophila melanogaster
-
-
-
1.14.16.4 Gallus gallus
-
-
-
1.14.16.4 Homo sapiens
-
-
-
1.14.16.4 Mus musculus
-
-
-
1.14.16.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.16.4 brain
-
 Mus musculus
-
1.14.16.4 brain
-
 Rattus norvegicus
-
1.14.16.4 neuron expressed predominantly in serotonergic neurons Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
 Gallus gallus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
 Drosophila melanogaster 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
 Mus musculus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
 Rattus norvegicus 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2
-
 Danio rerio 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?
1.14.16.4 L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 over 300 single nucleotide polymorphisms have been identified and are associated with symptoms ranging from mild hyperphenylalaninemia to severe phenylketonuria Homo sapiens 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.16.4 TPH2
-
 Gallus gallus
1.14.16.4 TPH2
-
 Drosophila melanogaster
1.14.16.4 TPH2
-
 Mus musculus
1.14.16.4 TPH2
-
 Homo sapiens
1.14.16.4 TPH2
-
 Rattus norvegicus
1.14.16.4 TPH2
-
 Danio rerio
1.14.16.4 tryptophan hydroxylase 2
-
 Gallus gallus
1.14.16.4 tryptophan hydroxylase 2
-
 Drosophila melanogaster
1.14.16.4 tryptophan hydroxylase 2
-
 Mus musculus
1.14.16.4 tryptophan hydroxylase 2
-
 Homo sapiens
1.14.16.4 tryptophan hydroxylase 2
-
 Rattus norvegicus
1.14.16.4 tryptophan hydroxylase 2
-
 Danio rerio