Literature summary extracted from

Madlener, S.; Illmer, C.; Horvath, Z.; Saiko, P.; Losert, A.; Herbacek, I.; Grusch, M.; Elford, H.L.; Krupitza, G.; Bernhaus, A.; Fritzer-Szekeres, M.; Szekeres, T.
Gallic acid inhibits ribonucleotide reductase and cyclooxygenases in human HL-60 promyelocytic leukemia cells (2007), Cancer Lett., 245, 156-162.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.17.4.2	gallic acid	inhibition of enzyme activity and induction of dose-dependent apoptosis and attenuated progression from G0/G1 to S phase of cells cycle. Highly synergistic effects of simultaneous treatment of cells with gallic acid and enzyme inhibitor N',3,4,5-tetrahydroxybenzenecarboximidamide	Homo sapiens
1.17.4.2	N',3,4,5-tetrahydroxybenzenecarboximidamide	i.e. trimidox, highly synergistic effects of simultaneous treatment of cells with inhibitors gallic acid and trimidox	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.17.4.2	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.17.4.2	HL-60 cell	promyelocytic leukemia cells	Homo sapiens	-

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Release 2023.1 (January 2023)