Literature summary extracted from

Tao, Y.H.; Yuan, Z.; Tang, X.Q.; Xu, H.B.; Yang, X.L.
Inhibition of GABA shunt enzymes activity by 4-hydroxybenzaldehyde derivatives (2006), Bioorg. Med. Chem. Lett., 16, 592-595.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.6.1.19	4-hydroxybenzaldehyde	IC50: 0.0165 mM, competitive inhibition	Homo sapiens
2.6.1.19	4-hydroxybenzylamine	IC50: 0.0154 mM, competitive inhibition	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.6.1.19	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.6.1.19	brain	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.6.1.19	4-aminobutanoate + 2-oxoglutarate	-	Homo sapiens	4-oxobutanoate + L-glutamate	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.6.1.19	GABA transaminase	-	Homo sapiens
2.6.1.19	GABA-T	-	Homo sapiens

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
2.6.1.19	pyridoxal 5'-phosphate	-	Homo sapiens

IC50 Value

EC Number	IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
2.6.1.19	0.0154	-	IC50: 0.0154 mM, competitive inhibition	Homo sapiens	4-hydroxybenzylamine
2.6.1.19	0.0165	-	IC50: 0.0165 mM, competitive inhibition	Homo sapiens	4-hydroxybenzaldehyde

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Release 2023.1 (January 2023)