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Literature summary extracted from
- N-Benzylbenzamides: A new class of potent tyrosinase inhibitors (2006), Bioorg. Med. Chem. Lett., 16, 2682-2684.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.10.3.1 | 2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.550 mM | Agaricus bisporus |  |
| 1.10.3.1 | 2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 1.820 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.555 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 1.180 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.280 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 2.0 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.705 mM | Agaricus bisporus | |
| 1.10.3.1 | 3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 0.710 mM | Agaricus bisporus | |
| 1.10.3.1 | kojic acid | IC50: 0.0163 mM | Agaricus bisporus | |
| 1.10.3.1 | N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide | IC50: 0.029 mM | Agaricus bisporus | |
| 1.10.3.1 | N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide | IC50: 0.017 mM | Agaricus bisporus | |
| 1.10.3.1 | N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide | IC50: 0.011 mM | Agaricus bisporus | |
| 1.10.3.1 | N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide | IC50: 0.0022 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzyl-2,4-dihydroxybenzamide | IC50: 1.660 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzyl-3,4,5-trihydroxybenzamide | IC50: 0.780 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzyl-3,4-dihydroxybenzamide | IC50: 2.0 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzyl-3,5-dihydroxybenzamide | IC50: 0.700 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzylamide | IC50: 1.990 mM | Agaricus bisporus | |
| 1.10.3.1 | N-benzylbenzamide derivatives | inhibitory potency, structure-activity relationships, overview | Agaricus bisporus | |
| 1.14.18.1 | 2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.550 mM | Agaricus bisporus | |
| 1.14.18.1 | 2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 1.820 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.555 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 1.180 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.280 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 2.0 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | IC50: 0.705 mM | Agaricus bisporus | |
| 1.14.18.1 | 3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide | IC50: 0.710 mM | Agaricus bisporus | |
| 1.14.18.1 | kojic acid | IC50: 0.0163 mM | Agaricus bisporus | |
| 1.14.18.1 | N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide | IC50: 0.029 mM | Agaricus bisporus | |
| 1.14.18.1 | N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide | IC50: 0.017 mM | Agaricus bisporus | |
| 1.14.18.1 | N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide | IC50: 0.011 mM | Agaricus bisporus | |
| 1.14.18.1 | N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide | IC50: 0.0022 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzyl-2,4-dihydroxybenzamide | IC50: 1.660 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzyl-3,4,5-trihydroxybenzamide | IC50: 0.780 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzyl-3,4-dihydroxybenzamide | IC50: 2.0 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzyl-3,5-dihydroxybenzamide | IC50: 0.700 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzylamide | IC50: 1.990 mM | Agaricus bisporus | |
| 1.14.18.1 | N-benzylbenzamide derivatives | inhibitory potency, structureactivity relationships, overview | Agaricus bisporus |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.10.3.1 | Cu2+ | copper enzyme | Agaricus bisporus | |
| 1.14.18.1 | Cu2+ | copper enzyme | Agaricus bisporus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.10.3.1 | Agaricus bisporus | - |
- |
- |
| 1.14.18.1 | Agaricus bisporus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.10.3.1 | commercial preparation | - |
Agaricus bisporus | - |
| 1.14.18.1 | commercial preparation | - |
Agaricus bisporus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.10.3.1 | L-DOPA + O2 | - |
Agaricus bisporus | ? | - |
? | |
| 1.10.3.1 | additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Agaricus bisporus | ? | - |
? | |
| 1.14.18.1 | L-DOPA + O2 | - |
Agaricus bisporus | ? | - |
? | |
| 1.14.18.1 | additional information | the enzyme catalyzes the hydroxylation of monophenols to o-diphenols, monophenolase activity EC 1.14.18.1, and the oxidation of the o-diphenols to o-quinones, diphenolase activity EC 1.10.3.1, cross-reaction analysis, overview | Agaricus bisporus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.10.3.1 | More | cf. EC 1.14.18.1 | Agaricus bisporus |
| 1.10.3.1 | tyrosinase | - |
Agaricus bisporus |
| 1.14.18.1 | More | cf. EC 1.10.3.1 | Agaricus bisporus |
| 1.14.18.1 | tyrosinase | - |
Agaricus bisporus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 1.10.3.1 | 0.0022 | - |
IC50: 0.0022 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide | |
| 1.10.3.1 | 0.011 | - |
IC50: 0.011 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide | |
| 1.10.3.1 | 0.0163 | - |
IC50: 0.0163 mM | Agaricus bisporus | kojic acid | |
| 1.10.3.1 | 0.017 | - |
IC50: 0.017 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide | |
| 1.10.3.1 | 0.029 | - |
IC50: 0.029 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide | |
| 1.10.3.1 | 0.28 | - |
IC50: 0.280 mM | Agaricus bisporus | 3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.10.3.1 | 0.55 | - |
IC50: 0.550 mM | Agaricus bisporus | 2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.10.3.1 | 0.555 | - |
IC50: 0.555 mM | Agaricus bisporus | 3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.10.3.1 | 0.7 | - |
IC50: 0.700 mM | Agaricus bisporus | N-benzyl-3,5-dihydroxybenzamide | |
| 1.10.3.1 | 0.705 | - |
IC50: 0.705 mM | Agaricus bisporus | 3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.10.3.1 | 0.71 | - |
IC50: 0.710 mM | Agaricus bisporus | 3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.10.3.1 | 0.78 | - |
IC50: 0.780 mM | Agaricus bisporus | N-benzyl-3,4,5-trihydroxybenzamide | |
| 1.10.3.1 | 1.18 | - |
IC50: 1.180 mM | Agaricus bisporus | 3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.10.3.1 | 1.66 | - |
IC50: 1.660 mM | Agaricus bisporus | N-benzyl-2,4-dihydroxybenzamide | |
| 1.10.3.1 | 1.82 | - |
IC50: 1.820 mM | Agaricus bisporus | 2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.10.3.1 | 1.99 | - |
IC50: 1.990 mM | Agaricus bisporus | N-benzylamide | |
| 1.10.3.1 | 2 | - |
IC50: 2.0 mM | Agaricus bisporus | N-benzyl-3,4-dihydroxybenzamide | |
| 1.10.3.1 | 2 | - |
IC50: 2.0 mM | Agaricus bisporus | 3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.0022 | - |
IC50: 0.0022 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,5-dihydroxybenzamide | |
| 1.14.18.1 | 0.011 | - |
IC50: 0.011 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,4-dihydroxybenzamide | |
| 1.14.18.1 | 0.0163 | - |
IC50: 0.0163 mM | Agaricus bisporus | kojic acid | |
| 1.14.18.1 | 0.017 | - |
IC50: 0.017 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-3,4,5-trihydroxybenzamide | |
| 1.14.18.1 | 0.029 | - |
IC50: 0.029 mM | Agaricus bisporus | N-(2,4-dihydroxybenzyl)-2,4-dihydroxybenzamide | |
| 1.14.18.1 | 0.28 | - |
IC50: 0.280 mM | Agaricus bisporus | 3,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.55 | - |
IC50: 0.550 mM | Agaricus bisporus | 2,4-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.555 | - |
IC50: 0.555 mM | Agaricus bisporus | 3,4,5-trihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.7 | - |
IC50: 0.700 mM | Agaricus bisporus | N-benzyl-3,5-dihydroxybenzamide | |
| 1.14.18.1 | 0.705 | - |
IC50: 0.705 mM | Agaricus bisporus | 3,5-dihydroxy-N-(3,4,5-trihydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.71 | - |
IC50: 0.710 mM | Agaricus bisporus | 3,5-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.14.18.1 | 0.78 | - |
IC50: 0.780 mM | Agaricus bisporus | N-benzyl-3,4,5-trihydroxybenzamide | |
| 1.14.18.1 | 1.18 | - |
IC50: 1.180 mM | Agaricus bisporus | 3,4,5-trihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.14.18.1 | 1.66 | - |
IC50: 1.660 mM | Agaricus bisporus | N-benzyl-2,4-dihydroxybenzamide | |
| 1.14.18.1 | 1.82 | - |
IC50: 1.820 mM | Agaricus bisporus | 2,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
| 1.14.18.1 | 1.99 | - |
IC50: 1.990 mM | Agaricus bisporus | N-benzylamide | |
| 1.14.18.1 | 2 | - |
IC50: 2.0 mM | Agaricus bisporus | N-benzyl-3,4-dihydroxybenzamide | |
| 1.14.18.1 | 2 | - |
IC50: 2.0 mM | Agaricus bisporus | 3,4-dihydroxy-N-(4-hydroxybenzyl)benzamide | |
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