EC Number | Application | Comment | Organism |
---|---|---|---|
1.3.1.9 | medicine | antibacterial target | Staphylococcus aureus |
1.3.1.9 | medicine | antibacterial target | Escherichia coli |
EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.9 | fabI gene from Escherichia coli DH5alpha was cloned into pBAD/Myc-His B vector for expression of the protein in Escherichia coli TOP10 cells | Escherichia coli |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.9 | (E)-1-benzyl-2-methyl-3-[2-(pyridin-3-yl)vinyl]-4-pyridone | IC50: higher than 0.100 mM | Escherichia coli | |
1.3.1.9 | 1,3-bis(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.0084 mM | Escherichia coli | |
1.3.1.9 | 1,3-bis(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 1,3-dibenzyl-2-methyl-4-pyridone | IC50: 0.020 mM | Escherichia coli | |
1.3.1.9 | 1,3-dibenzyl-2-methyl-4-pyridone | MIC (microg/mL): 64 | Staphylococcus aureus | |
1.3.1.9 | 1-(4-aminobenzyl)-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00029 mM | Escherichia coli | |
1.3.1.9 | 1-(4-aminobenzyl)-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 1 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-2-butyl-3-(2,6-dichlorobenzyl)-4-pyridone | IC50: 0.0045 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-2-butyl-3-(2,6-dichlorobenzyl)-4-pyridone | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-2-methyl-3-(2,4,6-trichlorobenzyl)-4-pyridone | IC50: 0.0015 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-2-methyl-3-(2,4,6-trichlorobenzyl)-4-pyridone | MIC (microg/ml): 8 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-2-methyl-3-phenyl-4-pyridone | IC50: 0.0029 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-2-methyl-3-vinyl-4-pyridone | IC50: higher than 0.100 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-2-methyl-3-[2-(pyridin-3-yl)ethyl]-4-pyridone | IC50: higher than 0.100 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,4-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.0020 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,4-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2,6-dichlorobenzyl)-2-ethyl-4-pyridone | IC50: 0.00078 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,6-dichlorobenzyl)-2-ethyl-4-pyridone | MIC (microg/ml): 8 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00030 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 0.5 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2,6-difluorobenzyl)-2-methyl-4-pyridone | IC50: 0.0027 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,6-difluorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 4 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2,6-dimethylbenzyl)-2-methyl-4-pyridone | IC50: 0.0043 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2,6-dimethylbenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 16 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2-chloro-6-fluorobenzyl)-2-methyl-4-pyridone | IC50: 0.00039 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2-chloro-6-fluorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 2 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-(2-chlorobenzyl)-2-methyl-4-pyridone | IC50: 0.0042 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-(2-chlorobenzyl)-2-methyl-4-pyridone | MIC (microg/mL): 64 | Staphylococcus aureus | |
1.3.1.9 | 1-benzyl-3-butyl-2-methyl-4-pyridone | IC50: 0.061 mM | Escherichia coli | |
1.3.1.9 | 1-benzyl-3-butyl-2-methyl-4-pyridone | MIC (microg/ml): higher than 128 | Staphylococcus aureus | |
1.3.1.9 | 1-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00031 mM | Escherichia coli | |
1.3.1.9 | 1-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 2 | Staphylococcus aureus | |
1.3.1.9 | 1-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00022 mM | Escherichia coli | |
1.3.1.9 | 1-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 0.25 | Staphylococcus aureus | |
1.3.1.9 | 1-decyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00022 mM | Escherichia coli | |
1.3.1.9 | 1-decyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1,2-dimethyl-4-pyridone | IC50: 0.011 mM | Escherichia coli | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1,2-dimethyl-4-pyridone | MIC (microg/ml): higher than 128 | Staphylococcus aureus | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-(4-nitrobenzyl)-2-methyl-4-pyridone | IC50: 0.0018 mM | Escherichia coli | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-(4-nitrobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 16 | Staphylococcus aureus | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-(5-hydroxypentyl)-2-methyl-4-pyridone | IC50: 0.0018 mM | Escherichia coli | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-(5-hydroxypentyl)-2-methyl-4-pyridone | MIC (microg/ml): 8 | Staphylococcus aureus | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-furfuryl-2-methyl-4-pyridone | IC50: 0.00047 mM | Escherichia coli | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-1-furfuryl-2-methyl-4-pyridone | MIC (microg/ml): 2 | Staphylococcus aureus | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.120 mM | Escherichia coli | |
1.3.1.9 | 3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): higher than 64 | Staphylococcus aureus | |
1.3.1.9 | 3-cyclohexylmethyl-1-benzyl-2-methyl-4-pyridone | IC50: 0.00040 mM | Escherichia coli | |
1.3.1.9 | 3-cyclohexylmethyl-1-benzyl-2-methyl-4-pyridone | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzamide | IC50: 0.0025 mM | Escherichia coli | |
1.3.1.9 | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzamide | MIC (microg/ml): 32 | Staphylococcus aureus | |
1.3.1.9 | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoic acid | IC50: 0.022 mM | Escherichia coli | |
1.3.1.9 | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoic acid | MIC (microg/ml): higher than 128 | Staphylococcus aureus | |
1.3.1.9 | 5-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]pentanoic acid | IC50: 0.110 mM | Escherichia coli | |
1.3.1.9 | 6-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00038 mM | Escherichia coli | |
1.3.1.9 | 6-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 8 | Staphylococcus aureus | |
1.3.1.9 | 6-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | IC50: 0.00029 mM | Escherichia coli | |
1.3.1.9 | 6-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | MIC (microg/ml): 2 | Staphylococcus aureus | |
1.3.1.9 | lead compound | MIC (microg/mL): 64 | Staphylococcus aureus | |
1.3.1.9 | methyl 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoate | IC50: 0.00030 mM | Escherichia coli | |
1.3.1.9 | methyl 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoate | MIC (microg/ml): higher than 128 | Staphylococcus aureus | |
1.3.1.9 | triclosan | IC50: 0.00051 mM | Escherichia coli | |
1.3.1.9 | triclosan | MIC (microg/ml): 0.125 | Staphylococcus aureus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | Staphylococcus aureus | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | Escherichia coli | - |
trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.9 | Escherichia coli | - |
- |
- |
1.3.1.9 | Staphylococcus aureus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.3.1.9 | using a Ni-NTA agarose column | Escherichia coli |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | - |
Staphylococcus aureus | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
1.3.1.9 | acyl-[acyl-carrier protein] + NAD+ | - |
Escherichia coli | trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ | - |
? | |
1.3.1.9 | crotonyl-CoA + NADH + H+ | activity assay | Escherichia coli | butyryl-CoA + NAD+ | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.3.1.9 | enoyl-ACP reductase | - |
Staphylococcus aureus |
1.3.1.9 | enoyl-ACP reductase | - |
Escherichia coli |
1.3.1.9 | enoyl-[acyl-carrier-protein] reductase | - |
Staphylococcus aureus |
1.3.1.9 | enoyl-[acyl-carrier-protein] reductase | - |
Escherichia coli |
1.3.1.9 | FabI | - |
Staphylococcus aureus |
1.3.1.9 | FabI | - |
Escherichia coli |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
1.3.1.9 | 20 | - |
FabI-inhibitory activity assay at room temperature | Escherichia coli |
1.3.1.9 | 35 | - |
antibacterial activity assay | Staphylococcus aureus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.9 | 7.4 | - |
FabI-inhibitory activity assay | Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.9 | NADH | - |
Staphylococcus aureus | |
1.3.1.9 | NADH | - |
Escherichia coli |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
1.3.1.9 | 0.00022 | - |
IC50: 0.00022 mM | Escherichia coli | 1-decyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.00022 | - |
IC50: 0.00022 mM | Escherichia coli | 1-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.00029 | - |
IC50: 0.00029 mM | Escherichia coli | 1-(4-aminobenzyl)-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.00029 | - |
IC50: 0.00029 mM | Escherichia coli | 6-cyclohexylmethyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0003 | - |
IC50: 0.00030 mM | Escherichia coli | 1-benzyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0003 | - |
IC50: 0.00030 mM | Escherichia coli | methyl 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoate | |
1.3.1.9 | 0.00031 | - |
IC50: 0.00031 mM | Escherichia coli | 1-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.00038 | - |
IC50: 0.00038 mM | Escherichia coli | 6-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.00039 | - |
IC50: 0.00039 mM | Escherichia coli | 1-benzyl-3-(2-chloro-6-fluorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0004 | - |
IC50: 0.00040 mM | Escherichia coli | 3-cyclohexylmethyl-1-benzyl-2-methyl-4-pyridone | |
1.3.1.9 | 0.00047 | - |
IC50: 0.00047 mM | Escherichia coli | 3-(2,6-dichlorobenzyl)-1-furfuryl-2-methyl-4-pyridone | |
1.3.1.9 | 0.00051 | - |
IC50: 0.00051 mM | Escherichia coli | triclosan | |
1.3.1.9 | 0.00078 | - |
IC50: 0.00078 mM | Escherichia coli | 1-benzyl-3-(2,6-dichlorobenzyl)-2-ethyl-4-pyridone | |
1.3.1.9 | 0.0015 | - |
IC50: 0.0015 mM | Escherichia coli | 1-benzyl-2-methyl-3-(2,4,6-trichlorobenzyl)-4-pyridone | |
1.3.1.9 | 0.0018 | - |
IC50: 0.0018 mM | Escherichia coli | 3-(2,6-dichlorobenzyl)-1-(5-hydroxypentyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0018 | - |
IC50: 0.0018 mM | Escherichia coli | 3-(2,6-dichlorobenzyl)-1-(4-nitrobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.002 | - |
IC50: 0.0020 mM | Escherichia coli | 1-benzyl-3-(2,4-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0025 | - |
IC50: 0.0025 mM | Escherichia coli | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzamide | |
1.3.1.9 | 0.0027 | - |
IC50: 0.0027 mM | Escherichia coli | 1-benzyl-3-(2,6-difluorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0029 | - |
IC50: 0.0029 mM | Escherichia coli | 1-benzyl-2-methyl-3-phenyl-4-pyridone | |
1.3.1.9 | 0.0042 | - |
IC50: 0.0042 mM | Escherichia coli | 1-benzyl-3-(2-chlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0043 | - |
IC50: 0.0043 mM | Escherichia coli | 1-benzyl-3-(2,6-dimethylbenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.0045 | - |
IC50: 0.0045 mM | Escherichia coli | 1-benzyl-2-butyl-3-(2,6-dichlorobenzyl)-4-pyridone | |
1.3.1.9 | 0.0084 | - |
IC50: 0.0084 mM | Escherichia coli | 1,3-bis(2,6-dichlorobenzyl)-2-methyl-4-pyridone | |
1.3.1.9 | 0.011 | - |
IC50: 0.011 mM | Escherichia coli | 3-(2,6-dichlorobenzyl)-1,2-dimethyl-4-pyridone | |
1.3.1.9 | 0.02 | - |
IC50: 0.020 mM | Escherichia coli | 1,3-dibenzyl-2-methyl-4-pyridone | |
1.3.1.9 | 0.022 | - |
IC50: 0.022 mM | Escherichia coli | 4-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]methylbenzoic acid | |
1.3.1.9 | 0.061 | - |
IC50: 0.061 mM | Escherichia coli | 1-benzyl-3-butyl-2-methyl-4-pyridone | |
1.3.1.9 | 0.1 | - |
IC50: higher than 0.100 mM | Escherichia coli | (E)-1-benzyl-2-methyl-3-[2-(pyridin-3-yl)vinyl]-4-pyridone | |
1.3.1.9 | 0.1 | - |
IC50: higher than 0.100 mM | Escherichia coli | 1-benzyl-2-methyl-3-[2-(pyridin-3-yl)ethyl]-4-pyridone | |
1.3.1.9 | 0.1 | - |
IC50: higher than 0.100 mM | Escherichia coli | 1-benzyl-2-methyl-3-vinyl-4-pyridone | |
1.3.1.9 | 0.11 | - |
IC50: 0.110 mM | Escherichia coli | 5-[3-(2,6-dichlorobenzyl)-2-methyl-4-pyridon-1-yl]pentanoic acid | |
1.3.1.9 | 0.12 | - |
IC50: 0.120 mM | Escherichia coli | 3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone |