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Literature summary extracted from

  • Farhanullah, R.J.; Kim, S.Y.; Yoon, E.J.; Choi, E.C.; Kim, S.; Kang, T.; Samrin, F.; Puri, S.; Lee, J.
    Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors (2006), Bioorg. Med. Chem., 14, 7154-7159.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-1-hydroxymethylpropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-hydroxypropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-2-methoxypropylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-4-hydroxybutylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 2-[3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
-
 Staphylococcus aureus
6.1.1.10 4-[3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-2-one
-
 Staphylococcus aureus
6.1.1.10 additional information in vitro minimum inhibitory concentrations of quinoline compounds with different strains of Staphylococcus aureus, structure-activity relationships Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
6.1.1.10 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
6.1.1.10 methionyl-tRNA synthetase
-
 Staphylococcus aureus
6.1.1.10 MRS
-
 Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
6.1.1.10 0.0000011
-
 isozyme MRSA Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-propylamino]-1H-quinolin-4-one
6.1.1.10 0.0000023
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-hydroxypropylamino]-1H-quinolin-4-one
6.1.1.10 0.0000025
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-2-methoxypropylamino]-1H-quinolin-4-one
6.1.1.10 0.0000029
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-4-hydroxybutylamino]-1H-quinolin-4-one
6.1.1.10 0.0000186
-
-
 Staphylococcus aureus 2-[3-(3,4-dichlorobenzylamino)-1-hydroxymethylpropylamino]-1H-quinolin-4-one
6.1.1.10 0.00495
-
-
 Staphylococcus aureus 4-[3-(3,4-dichlorobenzylamino)propylamino]-1H-quinolin-2-one