Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • de Beer, T.A.; Louw, A.I.; Joubert, F.
    Elucidation of sulfadoxine resistance with structural models of the bifunctional Plasmodium falciparum dihydropterin pyrophosphokinase-dihydropteroate synthase (2006), Bioorg. Med. Chem., 14, 4433-4443.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.5.1.15 more putative structural model of five mutations in DHPS to explain sulfadoxine resistance, structural model based on crystal structures of Saccharomyces cerevisiae (PPPK-DHPS), Mycobacterium tuberculosis (DHPS), Bacillus anthracis (DHPS), and Escherichia coli (PPPK) Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 sulfadoxine
-
Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.6.3 Mg2+
-
Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Plasmodium falciparum
-
diphosphate + 7,8-dihydropteroate
-
?
2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + ATP Plasmodium falciparum
-
6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Plasmodium falciparum Q27735 fragment of dihydropteroate synthase
-
2.7.6.3 Plasmodium falciparum Q27865
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Plasmodium falciparum diphosphate + 7,8-dihydropteroate
-
?
2.7.6.3 6-hydroxymethyl-7,8-dihydropterin + ATP
-
Plasmodium falciparum 6-hydroxymethyl-7,8-dihydropterin diphosphate + AMP
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
Plasmodium falciparum
2.5.1.15 DHPS
-
Plasmodium falciparum
2.5.1.15 dihydropteroate synthetase
-
Plasmodium falciparum
2.7.6.3 dihydropterin pyrophosphokinase
-
Plasmodium falciparum