Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Berselli, P.; Zava, S.; Sottocornola, E.; Milani, S.; Berra, B.; Colombo, I.
    Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein (2006), Biochim. Biophys. Acta, 1759, 348-358.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.9 cloning from HL-60 cells, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens
2.4.3.9 cloning from placenta, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens
2.4.3.9 type 1-4 isozymes, DNA and amino acid sequence determination and analysis, genetic organization of isozymes, mRNA variants differ in the 5'-untranslated region, in vitro transcription and translation using the rabbit reticulocyte lysate system, expression in murine MG1361 cells, a mammary adenocarcinoma cell line Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.9 microsome membrane and lumen Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.3.9 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide Homo sapiens
-
 CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.9 Homo sapiens
-
 5 different isozymes/mRNA variants of different lengths, overview
-
2.4.3.9 Homo sapiens Q9UNP4 SIAT9; 5 different isozymes/mRNA variants of different lengths, overview
-
2.4.3.9 Homo sapiens Q9UNP4 ST3GAL5, SIAT9; 5 different isozymes/mRNA variants of different lengths, overview
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.3.9 glycoprotein
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.9 brain fetal, isozymes type 1-4 Homo sapiens
-
2.4.3.9 HL-60 cell type 2 isozyme Homo sapiens
-
2.4.3.9 placenta type 5 isozyme Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.9 CMP-N-acetylneuraminate + asialoGM1
-
 Homo sapiens CMP + GM1
-
 ?
2.4.3.9 CMP-N-acetylneuraminate + asialoGM2
-
 Homo sapiens CMP + GM2
-
 ?
2.4.3.9 CMP-N-acetylneuraminate + galactosylceramide
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-ceramide
-
 ?
2.4.3.9 CMP-N-acetylneuraminate + lactosylceramide
-
 Homo sapiens CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-beta-D-glucosyl-ceramide
-
 ?
2.4.3.9 additional information substrate specificity of isozymes, no activity with GD3 and GM1a as acceptors, overview Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.4.3.9 More the isozyme transcripts differ in length and the proteins in molecular weight Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.3.9 GM3 synthase
-
 Homo sapiens
2.4.3.9 Sia-T1
-
 Homo sapiens
2.4.3.9 ST3Gal V
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.9 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.9 6.4
-
 assay at Homo sapiens