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Literature summary extracted from

  • Subbaiah, P.V.; Horvath, P.; Achar, S.B.
    Regulation of the activity and fatty acid specificity of lecithin-cholesterol acyltransferase by sphingomyelin and its metabolites, ceramide and ceramide phosphate (2006), Biochemistry, 45, 5029-5038.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.3.1.43 ceramide 30% activation, stimulation of synthesis of 20:4 cholesteryl ester and 18:2 cholesteryl ester, but not of 16:0 cholesteryl ester, a phosphocholine ether matrix abolishes the activation effect Homo sapiens

General Stability

EC Number General Stability Organism
2.3.1.43 the purified enzyme is instable Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.43 ceramide phosphate stronger physiologic inhibitory effect compared to sphingomyelin Homo sapiens
2.3.1.43 additional information no inhibition by ceramide Homo sapiens
2.3.1.43 sphingomyelin physiologic inhibitor, ceramide protects partially Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.43 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.43 additional information Homo sapiens the activity and fatty acid specificity of LCAT may be altered during the inflammatory response ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol Homo sapiens
-
 1-acylglycerophosphocholine + cholesteryl ester
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.43 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.43 native enzyme from plasma Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.1.43 plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.43 additional information the activity and fatty acid specificity of LCAT may be altered during the inflammatory response Homo sapiens ?
-
 ?
2.3.1.43 additional information fatty acid specificity of LCAT, overview Homo sapiens ?
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol
-
 Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?
2.3.1.43 phosphatidylcholine + cholesterol proteoliposome substrates Homo sapiens 1-acylglycerophosphocholine + cholesteryl ester
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.1.43 LCAT
-
 Homo sapiens
2.3.1.43 lecithin-cholesterol acyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.3.1.43 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.3.1.43 7.4
-
 assay at Homo sapiens