EC Number | Application | Comment | Organism |
---|---|---|---|
1.14.14.154 | agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Oculimacula yallundae |
1.14.14.154 | agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Blumeria graminis |
1.14.14.154 | agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Oculimacula acuformis |
1.14.14.154 | agriculture | the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens | Zymoseptoria tritici |
1.14.14.154 | medicine | the enzyme is a target for antifungal inhibitors | Candida albicans |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
1.14.14.154 | F180L | the naturally occuring mutation is responsible for the resistance to triazoles | Oculimacula acuformis |
1.14.14.154 | I381V | the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole | Zymoseptoria tritici |
1.14.14.154 | additional information | the enzyme shows a number of polymorphisms at the amino acid level | Oculimacula yallundae |
1.14.14.154 | additional information | the enzyme shows a number of polymorphisms at the amino acid level | Oculimacula acuformis |
1.14.14.154 | Y136F | a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole | Blumeria graminis |
1.14.14.154 | Y136F/K147Q | a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole | Blumeria graminis |
1.14.14.154 | Y137F | the naturally occuring mutation does not affect triazole sensitivity | Zymoseptoria tritici |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.14.14.154 | azole | the organism shows reduced azole-sensitivity | Zymoseptoria tritici | |
1.14.14.154 | epoxiconazole | - |
Zymoseptoria tritici | |
1.14.14.154 | imidazoles | - |
Oculimacula acuformis | |
1.14.14.154 | imidazoles | - |
Oculimacula yallundae | |
1.14.14.154 | additional information | the enzyme is highly resistant to triadimenol | Blumeria graminis | |
1.14.14.154 | additional information | Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles | Oculimacula acuformis | |
1.14.14.154 | Prochloraz | - |
Oculimacula yallundae | |
1.14.14.154 | prothioconazole | - |
Zymoseptoria tritici | |
1.14.14.154 | tebuconazole | - |
Zymoseptoria tritici | |
1.14.14.154 | triazole | - |
Blumeria graminis | |
1.14.14.154 | triazole | sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview | Candida albicans | |
1.14.14.154 | triazoles | - |
Oculimacula yallundae | |
1.14.14.154 | triazoles | - |
Zymoseptoria tritici |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.14.14.154 | Blumeria graminis | - |
f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51 | - |
1.14.14.154 | Candida albicans | - |
- |
- |
1.14.14.154 | Oculimacula acuformis | - |
syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51 | - |
1.14.14.154 | Oculimacula yallundae | - |
syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51 | - |
1.14.14.154 | Zymoseptoria tritici | - |
septoria leaf blotch fungus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.14.14.154 | additional information | residues Ile381 and Leu321 are involved in substrate recognition | Zymoseptoria tritici | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.14.14.154 | CYP51 | - |
Candida albicans |
1.14.14.154 | CYP51 | - |
Oculimacula yallundae |
1.14.14.154 | CYP51 | - |
Blumeria graminis |
1.14.14.154 | CYP51 | - |
Oculimacula acuformis |
1.14.14.154 | CYP51 | - |
Zymoseptoria tritici |
1.14.14.154 | cytochrome P450 sterol 14alpha-demethylase | - |
Candida albicans |