BRENDA - Enzyme Database

Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops

Cools, H.J.; Fraaije, B.A.; Kim, S.H.; Lucas, J.A.; Biochem. Soc. Trans. 34, 1219-1222 (2006) View publication on PubMed

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Oculimacula yallundae
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Blumeria graminis
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Oculimacula acuformis
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Zymoseptoria tritici
1.14.14.154
medicine
the enzyme is a target for antifungal inhibitors
Candida albicans
Engineering
EC Number
Protein Variants
Commentary
Organism
1.14.14.154
F180L
the naturally occuring mutation is responsible for the resistance to triazoles
Oculimacula acuformis
1.14.14.154
I381V
the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole
Zymoseptoria tritici
1.14.14.154
additional information
the enzyme shows a number of polymorphisms at the amino acid level
Oculimacula yallundae
1.14.14.154
additional information
the enzyme shows a number of polymorphisms at the amino acid level
Oculimacula acuformis
1.14.14.154
Y136F
a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole
Blumeria graminis
1.14.14.154
Y136F/K147Q
a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole
Blumeria graminis
1.14.14.154
Y137F
the naturally occuring mutation does not affect triazole sensitivity
Zymoseptoria tritici
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.154
azole
the organism shows reduced azole-sensitivity
Zymoseptoria tritici
1.14.14.154
epoxiconazole
-
Zymoseptoria tritici
1.14.14.154
imidazoles
-
Oculimacula acuformis
1.14.14.154
imidazoles
-
Oculimacula yallundae
1.14.14.154
additional information
the enzyme is highly resistant to triadimenol
Blumeria graminis
1.14.14.154
additional information
Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles
Oculimacula acuformis
1.14.14.154
Prochloraz
-
Oculimacula yallundae
1.14.14.154
prothioconazole
-
Zymoseptoria tritici
1.14.14.154
tebuconazole
-
Zymoseptoria tritici
1.14.14.154
triazole
-
Blumeria graminis
1.14.14.154
triazole
sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview
Candida albicans
1.14.14.154
triazoles
-
Oculimacula yallundae
1.14.14.154
triazoles
-
Zymoseptoria tritici
Organism
EC Number
Organism
UniProt
Commentary
Textmining
1.14.14.154
Blumeria graminis
-
f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51
-
1.14.14.154
Candida albicans
-
-
-
1.14.14.154
Oculimacula acuformis
-
syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51
-
1.14.14.154
Oculimacula yallundae
-
syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51
-
1.14.14.154
Zymoseptoria tritici
-
septoria leaf blotch fungus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
Substrate Product ID
1.14.14.154
additional information
residues Ile381 and Leu321 are involved in substrate recognition
671942
Zymoseptoria tritici
?
-
-
-
?
Synonyms
EC Number
Synonyms
Commentary
Organism
1.14.14.154
CYP51
-
Candida albicans
1.14.14.154
CYP51
-
Oculimacula yallundae
1.14.14.154
CYP51
-
Blumeria graminis
1.14.14.154
CYP51
-
Oculimacula acuformis
1.14.14.154
CYP51
-
Zymoseptoria tritici
1.14.14.154
cytochrome P450 sterol 14alpha-demethylase
-
Candida albicans
Application (protein specific)
EC Number
Application
Commentary
Organism
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Oculimacula yallundae
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Blumeria graminis
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Oculimacula acuformis
1.14.14.154
agriculture
the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens
Zymoseptoria tritici
1.14.14.154
medicine
the enzyme is a target for antifungal inhibitors
Candida albicans
Engineering (protein specific)
EC Number
Protein Variants
Commentary
Organism
1.14.14.154
F180L
the naturally occuring mutation is responsible for the resistance to triazoles
Oculimacula acuformis
1.14.14.154
I381V
the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole
Zymoseptoria tritici
1.14.14.154
additional information
the enzyme shows a number of polymorphisms at the amino acid level
Oculimacula yallundae
1.14.14.154
additional information
the enzyme shows a number of polymorphisms at the amino acid level
Oculimacula acuformis
1.14.14.154
Y136F
a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole
Blumeria graminis
1.14.14.154
Y136F/K147Q
a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole
Blumeria graminis
1.14.14.154
Y137F
the naturally occuring mutation does not affect triazole sensitivity
Zymoseptoria tritici
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.14.14.154
azole
the organism shows reduced azole-sensitivity
Zymoseptoria tritici
1.14.14.154
epoxiconazole
-
Zymoseptoria tritici
1.14.14.154
imidazoles
-
Oculimacula yallundae
1.14.14.154
imidazoles
-
Oculimacula acuformis
1.14.14.154
additional information
Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles
Oculimacula acuformis
1.14.14.154
additional information
the enzyme is highly resistant to triadimenol
Blumeria graminis
1.14.14.154
Prochloraz
-
Oculimacula yallundae
1.14.14.154
prothioconazole
-
Zymoseptoria tritici
1.14.14.154
tebuconazole
-
Zymoseptoria tritici
1.14.14.154
triazole
-
Blumeria graminis
1.14.14.154
triazole
sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview
Candida albicans
1.14.14.154
triazoles
-
Oculimacula yallundae
1.14.14.154
triazoles
-
Zymoseptoria tritici
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ID
1.14.14.154
additional information
residues Ile381 and Leu321 are involved in substrate recognition
671942
Zymoseptoria tritici
?
-
-
-
?