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Literature summary extracted from

  • Cools, H.J.; Fraaije, B.A.; Kim, S.H.; Lucas, J.A.
    Impact of changes in the target P450 CYP51 enzyme associated with altered triazole-sensitivity in fungal pathogens of cereal crops (2006), Biochem. Soc. Trans., 34, 1219-1222.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.154 agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Oculimacula yallundae
1.14.14.154 agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Blumeria graminis
1.14.14.154 agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Oculimacula acuformis
1.14.14.154 agriculture the enzyme is a target for antifungal inhibitors in protection of crops against fungal pathogens Zymoseptoria tritici
1.14.14.154 medicine the enzyme is a target for antifungal inhibitors Candida albicans

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.154 F180L the naturally occuring mutation is responsible for the resistance to triazoles Oculimacula acuformis
1.14.14.154 I381V the naturally occuring mutation causes resistance against triazole inhibitors epoxiconazole and tebuconazole Zymoseptoria tritici
1.14.14.154 additional information the enzyme shows a number of polymorphisms at the amino acid level Oculimacula yallundae
1.14.14.154 additional information the enzyme shows a number of polymorphisms at the amino acid level Oculimacula acuformis
1.14.14.154 Y136F a naturally occuring mutation in both wheat and barley powdery mildew that leads to resistance or low sensitivity against triazole Blumeria graminis
1.14.14.154 Y136F/K147Q a naturally occuring double mutation in barley powdery mildew that leads to high resistance against triazole Blumeria graminis
1.14.14.154 Y137F the naturally occuring mutation does not affect triazole sensitivity Zymoseptoria tritici

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.154 azole the organism shows reduced azole-sensitivity Zymoseptoria tritici
1.14.14.154 epoxiconazole
-
Zymoseptoria tritici
1.14.14.154 imidazoles
-
Oculimacula acuformis
1.14.14.154 imidazoles
-
Oculimacula yallundae
1.14.14.154 additional information the enzyme is highly resistant to triadimenol Blumeria graminis
1.14.14.154 additional information Oculimacula acuformis is intrinsically resistant to triazoles and sensitive to imidazoles Oculimacula acuformis
1.14.14.154 Prochloraz
-
Oculimacula yallundae
1.14.14.154 prothioconazole
-
Zymoseptoria tritici
1.14.14.154 tebuconazole
-
Zymoseptoria tritici
1.14.14.154 triazole
-
Blumeria graminis
1.14.14.154 triazole sensitive and resistant variants of CYP51A1, mutations lead to alterations in the enzyme as drug target, primary determinants of triazole resistance, overview Candida albicans
1.14.14.154 triazoles
-
Oculimacula yallundae
1.14.14.154 triazoles
-
Zymoseptoria tritici

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.154 Blumeria graminis
-
f. sp. hordei or f. sp. tritici, barley or wheat powdery mildew, gene CYP51
-
1.14.14.154 Candida albicans
-
-
-
1.14.14.154 Oculimacula acuformis
-
syn. Tapesia acuformis, cereal eyespot fungi, gene CYP51
-
1.14.14.154 Oculimacula yallundae
-
syn. Tapesia yallundae, cereal eyespot fungi, gene CYP51
-
1.14.14.154 Zymoseptoria tritici
-
septoria leaf blotch fungus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.154 additional information residues Ile381 and Leu321 are involved in substrate recognition Zymoseptoria tritici ?
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.154 CYP51
-
Candida albicans
1.14.14.154 CYP51
-
Oculimacula yallundae
1.14.14.154 CYP51
-
Blumeria graminis
1.14.14.154 CYP51
-
Oculimacula acuformis
1.14.14.154 CYP51
-
Zymoseptoria tritici
1.14.14.154 cytochrome P450 sterol 14alpha-demethylase
-
Candida albicans