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Literature summary extracted from

  • Senda, M.; Ito, A.; Tsuchida, A.; Hagiwara, T.; Kaneda, T.; Nakamura, Y.; Kasama, K.; Kiso, M.; Yoshikawa, K.; Katagiri, Y.; Ono, Y.; Ogiso, M.; Urano, T.; Furukawa, K.; Oshima, S.; Furukawa, K.
    Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers (2007), Biochem. J., 402, 459-470.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
2.4.3.7 medicine the expression profiles of isoform ST6GalNAc VI among 20 renal cancer cell lines correlates clearly with those of disialylgalactosylgloboside, suggesting that the sialyltransferase involved in the synthesis of disialylgalactosylgloboside in the kidney is ST6GalNAc-VI. ST6GalNAc-VI and disialylgalactosylgloboside are found in proximal tubule epithelial cells in normal kidney tissues, while they are downregulated in renal cancer cell lines and cancer tissues Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.3.7 co-expression of ST6GalNAc VI and ST6GalNAc III with disialylgalactosylgloboside in Caki-1 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.3.7 membrane
-
 Homo sapiens 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.3.7 Mg2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.3.7 CMP-NAC + monosialylgalactosylgloboside Homo sapiens the enzyme is responsible for the synthesis of disialylgalactosylgloboside from monosialylgalactosylgloboside in normal and malignant kidney cells, the reaction suppressed during the malignant transformation of the proximal tubules as a maturation arrest of glycosylation, overview CMP + disialylgalactosylgloboside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.3.7 Homo sapiens
-
 isoforms ST6GalNAc III, V, and VI
-
2.4.3.7 Homo sapiens Q8NDV1 ST6GalNAc III
-
2.4.3.7 Homo sapiens Q969X2 ST6GalNAc VI
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.3.7 brain expression of ST6GalNAc III Homo sapiens
-
2.4.3.7 brain expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 Caki-1 cell
-
 Homo sapiens
-
2.4.3.7 colon expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 epithelial cell expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 heart expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 kidney in proximal tubule epithelial cells, expression of ST6GalNAc III Homo sapiens
-
2.4.3.7 kidney in proximal tubule epithelial cells, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 kidney isoform ST6GalNAc-VI and disialylgalactosylgloboside are found in proximal tubule epithelial cells in normal kidney tissues Homo sapiens
-
2.4.3.7 liver expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 lung expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 additional information ST6GalNAc III tissue expression pattern, in situ hybridization, overview Homo sapiens
-
2.4.3.7 additional information ST6GalNAc VI tissue expression pattern, ST6GalNAc VI is downregulated in renal cancer cell lines and cancer tissues, in situ hybridization, overview Homo sapiens
-
2.4.3.7 Moroff cell
-
 Homo sapiens
-
2.4.3.7 Moroff cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 muscle expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 OS-RC-2 cell
-
 Homo sapiens
-
2.4.3.7 placenta expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 RCC-10RGB cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 1 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 1 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 17 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 17 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 29 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 29 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 35 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 35 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 39 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 39 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 44 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 44 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 45 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 6 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 6 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 7 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 7 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC 99 cell
-
 Homo sapiens
-
2.4.3.7 SK-RC 99 cell renal cancer cell line, expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 SK-RC-45 cell
-
 Homo sapiens
-
2.4.3.7 small intestine expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 spleen expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 stomach expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 testis expression of ST6GalNAc VI Homo sapiens
-
2.4.3.7 TUHR-10TKB cell
-
 Homo sapiens
-
2.4.3.7 TUHR-14TKB cell
-
 Homo sapiens
-
2.4.3.7 TUHR-4TKB cell
-
 Homo sapiens
-
2.4.3.7 VMRC-RCW cell
-
 Homo sapiens
-
2.4.3.7 VMRC-RCZ cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.3.7 CMP-N-acetylneuraminate + monosialylgalactosylgloboside isoforms ST6GalNAc III and ST6GalNAc VI generate disialylgalactosylgloboside from monosialylgalactosylgloboside with Vmax/Km values of 1.91 and 4.16 respectively Homo sapiens CMP + disialylgalactosylgloboside
-
 ?
2.4.3.7 CMP-NAC + monosialylgalactosylgloboside
-
 Homo sapiens CMP + disialylgalactosylgloboside
-
 ?
2.4.3.7 CMP-NAC + monosialylgalactosylgloboside the enzyme is responsible for the synthesis of disialylgalactosylgloboside from monosialylgalactosylgloboside in normal and malignant kidney cells, the reaction suppressed during the malignant transformation of the proximal tubules as a maturation arrest of glycosylation, overview Homo sapiens CMP + disialylgalactosylgloboside
-
 ?
2.4.3.7 CMP-NeuAc + glycoprotein
-
 Homo sapiens ?
-
 ?
2.4.3.7 CMP-NeuAc + glycosphingolipid
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.3.7 ST6GalNAc III
-
 Homo sapiens
2.4.3.7 ST6GalNAc VI
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.3.7 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.3.7 6
-
 assay at Homo sapiens