Any feedback?
Literature summary extracted from
- Biochemical conservation of recombinant Drosophila tyrosine hydroxylase with its mammalian cognates (2005), Biochem. Genet., 43, 425-443.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | 1,4-dithiothreitol | 48% activity without dithiotreitol | Drosophila melanogaster |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.16.2 | expression Escherichia coli BL21(DE33) | Drosophila melanogaster |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | 3-iodotyrosine | - |
Drosophila melanogaster | |
| 1.14.16.2 | alpha-methyl-p-tyrosine | - |
Drosophila melanogaster | |
| 1.14.16.2 | dopamine | - |
Drosophila melanogaster | |
| 1.14.16.2 | epinephrine | - |
Drosophila melanogaster | |
| 1.14.16.2 | L-Dopa | - |
Drosophila melanogaster | |
| 1.14.16.2 | L-phenylalanine | - |
Drosophila melanogaster | |
| 1.14.16.2 | norepinephrine | - |
Drosophila melanogaster | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | Fe2+ | activating | Drosophila melanogaster | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | Drosophila melanogaster | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 1.14.16.2 | phosphoprotein | the enzyme is activated by cAMP-dependent protein kinase in vitro | Drosophila melanogaster |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.16.2 | cell culture | - |
Drosophila melanogaster | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.16.2 | L-tyrosine + 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine + O2 | - |
Drosophila melanogaster | 3,4-dihydroxyphenylalanine + ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.16.2 | TH | - |
Drosophila melanogaster |
| 1.14.16.2 | tyrosine hydroxylase | - |
Drosophila melanogaster |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.16.2 | 31 | - |
- |
Drosophila melanogaster |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.16.2 | 6,7-dimethyl-2-amino-4-hydroxy-5,6,7,8-tetrahydopteridine | strictly requirred | Drosophila melanogaster | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
