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Literature summary extracted from

  • Selvakumar, D.; Miyamoto, M.; Furuichi, Y.; Komiyama, T.
    Inhibition of fungal beta-1,3-glucan synthase and cell growth by HM-1 killer toxin single-chain anti-idiotypic antibodies (2006), Antimicrob. Agents Chemother., 50, 3090-3097.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.34 HM-1 HM-1 inhibits the growth of yeast cells by forming a pore at the growing tip of the daughter cell, resulting in the formation of a protruding structure and eventual cell death. Candida albicans
2.4.1.34 HM-1 HM-1 inhibits the growth of yeast cells by forming a pore at the growing tip of the daughter cell, resulting in the formation of a protruding structure and eventual cell death. Candida parapsilosis
2.4.1.34 HM-1 HM-1 inhibits the growth of yeast cells by forming a pore at the growing tip of the daughter cell, resulting in the formation of a protruding structure and eventual cell death. Candida tropicalis
2.4.1.34 HM-1 HM-1 inhibits the growth of yeast cells by forming a pore at the growing tip of the daughter cell, resulting in the formation of a protruding structure and eventual cell death. Nakaseomyces glabratus
2.4.1.34 HM-1 HM-1 inhibits the growth of yeast cells by forming a pore at the growing tip of the daughter cell, resulting in the formation of a protruding structure and eventual cell death. Saccharomyces cerevisiae
2.4.1.34 monomeric single-chain variable fragment (scFv) All four scFvs (scFv-A1, scFv-A2, scFv-A3, scFv-A4) inhibit beta-1,3-glucan-synthase. Most cultured cells treated with scFvs (3h) have a pearlike structure with protruding materials, characteristic of pore formation and similar to the morphology change after treatment with HM-1. These clearly indicate that the scFvs appear to have the same effect as HM-1 on sensitive yeast cells. Candida albicans
2.4.1.34 monomeric single-chain variable fragment (scFv) All four scFvs (scFv-A1, scFv-A2, scFv-A3, scFv-A4) inhibit beta-1,3-glucan-synthase. Most cultured cells treated with scFvs (3h) have a pearlike structure with protruding materials, characteristic of pore formation and similar to the morphology change after treatment with HM-1. These clearly indicate that the scFvs appear to have the same effect as HM-1 on sensitive yeast cells. Candida parapsilosis
2.4.1.34 monomeric single-chain variable fragment (scFv) All four scFvs (scFv-A1, scFv-A2, scFv-A3, scFv-A4) inhibit beta-1,3-glucan-synthase. Most cultured cells treated with scFvs (3h) have a pearlike structure with protruding materials, characteristic of pore formation and similar to the morphology change after treatment with HM-1. These clearly indicate that the scFvs appear to have the same effect as HM-1 on sensitive yeast cells. Candida tropicalis
2.4.1.34 monomeric single-chain variable fragment (scFv) All four scFvs (scFv-A1, scFv-A2, scFv-A3, scFv-A4) inhibit beta-1,3-glucan-synthase. Most cultured cells treated with scFvs (3h) have a pearlike structure with protruding materials, characteristic of pore formation and similar to the morphology change after treatment with HM-1. These clearly indicate that the scFvs appear to have the same effect as HM-1 on sensitive yeast cells. Nakaseomyces glabratus
2.4.1.34 monomeric single-chain variable fragment (scFv) All four scFvs (scFv-A1, scFv-A2, scFv-A3, scFv-A4) inhibit beta-1,3-glucan-synthase. Most cultured cells treated with scFvs (3h) have a pearlike structure with protruding materials, characteristic of pore formation and similar to the morphology change after treatment with HM-1. These clearly indicate that the scFvs appear to have the same effect as HM-1 on sensitive yeast cells. Saccharomyces cerevisiae
2.4.1.34 additional information Preincubation with nMAb-KT eliminate the inhibition of Candida growth by scFv antibodies, suggestig that the observed cytocidal effect of scFv antibodies is due to their structural resemblance to HM-1. Candida albicans
2.4.1.34 additional information Preincubation with nMAb-KT eliminate the inhibition of Candida growth by scFv antibodies, suggestig that the observed cytocidal effect of scFv antibodies is due to their structural resemblance to HM-1. Candida parapsilosis
2.4.1.34 additional information Preincubation with nMAb-KT eliminate the inhibition of Candida growth by scFv antibodies, suggestig that the observed cytocidal effect of scFv antibodies is due to their structural resemblance to HM-1. Candida tropicalis
2.4.1.34 additional information Preincubation with nMAb-KT eliminate the inhibition of Candida growth by scFv antibodies, suggestig that the observed cytocidal effect of scFv antibodies is due to their structural resemblance to HM-1. Nakaseomyces glabratus
2.4.1.34 additional information Preincubation with nMAb-KT eliminate the inhibition of Candida growth by scFv antibodies, suggestig that the observed cytocidal effect of scFv antibodies is due to their structural resemblance to HM-1. Saccharomyces cerevisiae

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.34 Candida albicans
-
-
-
2.4.1.34 Candida parapsilosis
-
-
-
2.4.1.34 Candida tropicalis
-
-
-
2.4.1.34 Nakaseomyces glabratus
-
-
-
2.4.1.34 Saccharomyces cerevisiae
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.4.1.34 beta-1,3-glucan synthase
-
 Nakaseomyces glabratus
2.4.1.34 beta-1,3-glucan synthase
-
 Saccharomyces cerevisiae
2.4.1.34 beta-1,3-glucan synthase
-
 Candida albicans
2.4.1.34 beta-1,3-glucan synthase
-
 Candida tropicalis
2.4.1.34 beta-1,3-glucan synthase
-
 Candida parapsilosis