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Literature summary extracted from

  • Iliades, P.; Meshnick, S.R.; Macreadie, I.G.
    Mutations in the Pneumocystis jirovecii DHPS gene confer cross-resistance to sulfa drugs (2005), Antimicrob. Agents Chemother., 49, 741-748.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.15 expression in Escherichia coli Pneumocystis jirovecii

Protein Variants

EC Number Protein Variants Comment Organism
2.5.1.15 P519S mutant with implicated sulfa drug resistance Pneumocystis jirovecii
2.5.1.15 T517A mutant with implicated sulfa drug resistance Pneumocystis jirovecii

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.15 dapsone
-
Pneumocystis jirovecii
2.5.1.15 sulfacetamide
-
Pneumocystis jirovecii
2.5.1.15 sulfachlorpyridazine
-
Pneumocystis jirovecii
2.5.1.15 Sulfadiazine
-
Pneumocystis jirovecii
2.5.1.15 sulfadimethoxine
-
Pneumocystis jirovecii
2.5.1.15 sulfadoxine
-
Pneumocystis jirovecii
2.5.1.15 sulfamerazine
-
Pneumocystis jirovecii
2.5.1.15 sulfamethoxazole
-
Pneumocystis jirovecii
2.5.1.15 sulfamethoxypyridazine
-
Pneumocystis jirovecii
2.5.1.15 sulfamoxole
-
Pneumocystis jirovecii
2.5.1.15 sulfanilamide
-
Pneumocystis jirovecii
2.5.1.15 sulfapyridine
-
Pneumocystis jirovecii
2.5.1.15 sulfaquinoxaline
-
Pneumocystis jirovecii
2.5.1.15 sulfathiazole
-
Pneumocystis jirovecii
2.5.1.15 sulfisoxazole
-
Pneumocystis jirovecii

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Pneumocystis jirovecii
-
diphosphate + 7,8-dihydropteroate
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.15 Pneumocystis jirovecii Q9UUP4
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
Pneumocystis jirovecii diphosphate + 7,8-dihydropteroate
-
?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
Pneumocystis jirovecii
2.5.1.15 DHPS
-
Pneumocystis jirovecii
2.5.1.15 dihydropteroate synthetase
-
Pneumocystis jirovecii