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Literature summary extracted from

  • Sekiguchi, J.; Tharavichitkul, P.; Miyoshi-Akiyama, T.; Chupia, V.; Fujino, T.; Araake, M.; Irie, A.; Morita, K.; Kuratsuji, T.; Kirikae, T.
    Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454) (2005), Antimicrob. Agents Chemother., 49, 3948-3951.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.5.1.3
-
 Staphylococcus aureus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 trimethoprim 50% inhibition at 0.254 mM Staphylococcus aureus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.3 0.00238
-
 NADPH
-
 Staphylococcus aureus
1.5.1.3 0.00268
-
 7,8-dihydrofolate
-
 Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Staphylococcus aureus
-
 trimethoprim-resistant enzyme
-
1.5.1.3 Staphylococcus aureus CM.S2
-
 trimethoprim-resistant enzyme
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Staphylococcus aureus 5,6,7,8-tetrahydrofolate + NADP+
-
 ?
1.5.1.3 7,8-dihydrofolate + NADPH
-
 Staphylococcus aureus CM.S2 5,6,7,8-tetrahydrofolate + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.5.1.3 S3DHFR
-
 Staphylococcus aureus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.3 NADPH
-
 Staphylococcus aureus