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Literature summary extracted from

  • Djaman, J.A.; Mazabraud, A.; Basco, L.
    Sulfadoxine-pyrimethamine susceptibilities and analysis of the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum isolates from Cote d'Ivoire (2007), Ann. Trop. Med. Parasitol., 101, 103-112.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.5.1.3 medicine study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reductase is associated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum

Protein Variants

EC Number Protein Variants Comment Organism
1.5.1.3 additional information study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reductase is associated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum
2.5.1.15 A437G little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum
2.5.1.15 A613S little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum
2.5.1.15 additional information assessment of mutations in DHPS in West Africa Plasmodium falciparum
2.5.1.15 S436A little association with between mutantion and sulfa drug resistance in patients Plasmodium falciparum

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.3 pyrimethamine study on Plasmodium falciparum isolates from 118 children in Cote d'Ivoire. 39.5% are highly resistant to pyrimethamine, with IC50 values above 2000 nM. 39% of the isolates have mutant dihydrofolate reductase and 94% mutant dihydropteroate synthetase genes, and mutant dihydrofolate reducatase is assovciated with resistance to pyrimethamine in vivo and in vitro Plasmodium falciparum
2.5.1.15 pyrimethamine
-
 Plasmodium falciparum
2.5.1.15 sulfadoxine-pyrimethamine
-
 Plasmodium falciparum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate Plasmodium falciparum
-
 diphosphate + 7,8-dihydropteroate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.3 Plasmodium falciparum
-
 isolates from Cote d'Ivoire
-
2.5.1.15 Plasmodium falciparum Q27735 fragment of dihydropteroate synthase
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.15 bloodstream form
-
 Plasmodium falciparum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.15 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate
-
 Plasmodium falciparum diphosphate + 7,8-dihydropteroate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.5.1.15 7,8-dihydropteroate synthase
-
 Plasmodium falciparum
2.5.1.15 DHPS
-
 Plasmodium falciparum
2.5.1.15 dihydropteroate synthetase
-
 Plasmodium falciparum