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Literature summary extracted from

  • Schaefer, C.; Hoffmann, L.; Heldt, K.; Lornejad-Schaefer, M.R.; Brauers, G.; Gehrmann, T.; Garrow, T.A.; Haeussinger, D.; Mayatepek, E.; Schwahn, B.C.; Schliess, F.
    Osmotic regulation of betaine homocysteine-S-methyltransferase expression in H4IIE rat hepatoma cells (2007), Am. J. Physiol. Gastrointest. Liver Physiol., 292, G1089-G1098.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.5 additional information after 24 h, Bhmt expression increases 1.53fold under hypoosmotic conditions, Bhmt enzymatic activity is altered under anisoosmotic conditions Rattus norvegicus

Application

EC Number Application Comment Organism
2.1.1.5 molecular biology osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally lead to metabolic alterations that depend on the availability of betaine-derived methyl groups Rattus norvegicus
2.1.1.5 additional information Bhmt expression is strongly regulated by changes in ambient osmolarity, osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally leads to metabolic alterations that depend on the availability of betaine-derived methyl groups Mus musculus
2.1.1.5 additional information Bhmt expression is strongly regulated by changes in ambient osmolarity, osmotic regulation of BHMT may be part of a cell volume-regulatory response and additionally leads to metabolic alterations that depend on the availability of betaine-derived methyl groups Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.5 actinomycin D leads to a decay of Bhmt mRNA, irrespective of the ambient osmolarity, at 120 min after addition, Bhmt mRNA levels are significantly decreased under hyperosmotic conditions, compared with the Bhmt mRNA levels found under the respective normo- or hypoosmotic condition Rattus norvegicus
2.1.1.5 additional information osmosensitivity of Bhmt mRNA expression Mus musculus
2.1.1.5 additional information hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression, suggesting that cell shrinkage rather than increased ionic strength or hyperosmolarity per se is the trigger, osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.5 Mus musculus
-
 male B57CL/6 mice
-
2.1.1.5 Rattus norvegicus
-
-
-
2.1.1.5 Rattus norvegicus O09171
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.5 H4IIE cell
-
 Rattus norvegicus
-
2.1.1.5 hepatocyte
-
 Mus musculus
-
2.1.1.5 hepatoma cell line hyperosmolarity (405 mosmol/l) suppresses Bhmt mRNA expression whereas hypoosmotic (205 mosmol/l) conditions induce Bhmt mRNA expression. Like hyperosmotic NaCl, hyperosmotic raffinose but not hyperosmotic urea suppresses Bhmt mRNA expression. Osmosensitivity of Bhmt mRNA expression is impaired by inhibitors of tyrosine kinases and cyclic nucleotide-dependent kinases Rattus norvegicus
-
2.1.1.5 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.5 L-homocysteine + betaine
-
 Rattus norvegicus L-methionine + dimethylglycine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.5 betaine-homocysteine S-methyltransferase
-
 Rattus norvegicus
2.1.1.5 BHMT
-
 Mus musculus
2.1.1.5 BHMT
-
 Rattus norvegicus