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Literature summary extracted from

  • Ratnam, S.; Wijekoon, E.P.; Hall, B.; Garrow, T.A.; Brosnan, M.E.; Brosnan, J.T.
    Effects of diabetes and insulin on betaine-homocysteine S-methyltransferase expression in rat liver (2006), Am. J. Physiol. Endocrinol. Metab., 290, E933-E939.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.5 additional information triamcinolone increases the level and rate of BHMT mRNA synthesis in H4IIE cells Rattus norvegicus
2.1.1.5 streptozotocin increases BHMT activity and mRNA levels in the liver Rattus norvegicus

Application

EC Number Application Comment Organism
2.1.1.5 medicine decreased plasma homocysteine in various models of diabetes may be due to enhanced homocysteine removal brought about by a combination of increased transsulfuration of homocysteine to cysteine and increased remethylation of homocysteine to methionine by BHMT Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.5 additional information insulin decreases the abundance of BHMT mRNA and the rate of de novo mRNA transcription of the gene in H4IIE cells, plays a direct role in the regulation of BHMT transcription Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.5 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.5 H4IIE cell
-
 Rattus norvegicus
-
2.1.1.5 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.5 L-homocysteine + betaine
-
 Rattus norvegicus L-methionine + dimethylglycine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.5 betaine-homocysteine methyltransferase
-
 Rattus norvegicus
2.1.1.5 BHMT
-
 Rattus norvegicus