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Literature summary extracted from

  • Kalinina, O.V.; Gelfand, M.S.
    Amino acid residues that determine functional specificity of NADP- and NAD-dependent isocitrate and isopropylmalate dehydrogenases (2006), Proteins, 64, 1001-1009.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Thermus thermophilus
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Leptospira interrogans
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Clostridium pasteurianum
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Bacteroides fragilis
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Brassica napus
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Arthrospira platensis
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Acidithiobacillus ferrooxidans
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Azotobacter vinelandii
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Agrobacterium tumefaciens
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Saccharomyces cerevisiae
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Aspergillus niger
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Zymoseptoria tritici
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Eremothecium gossypii
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Ogataea angusta
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Cyberlindnera jadinii
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview [Candida] boidinii
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Scheffersomyces stipitis
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Candida maltosa
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Escherichia coli
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Mycobacterium tuberculosis variant bovis
1.1.1.85 phylogenetic analysis, comparison to isocitrate dehydrogenase, EC 1.1.1.41, overview Thermus aquaticus

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Escherichia coli
-
-
-
1.1.1.85 Acidithiobacillus ferrooxidans Q56268 gene leuB
-
1.1.1.85 Agrobacterium tumefaciens P24404 gene leuB
-
1.1.1.85 Arthrospira platensis Q00412
-
-
1.1.1.85 Aspergillus niger P87256 gene leu2A
-
1.1.1.85 Azotobacter vinelandii P96197
-
-
1.1.1.85 Bacteroides fragilis P54354 gene leuB
-
1.1.1.85 Brassica napus P29102
-
-
1.1.1.85 Candida maltosa P07139 gene leu2
-
1.1.1.85 Clostridium pasteurianum P31958
-
-
1.1.1.85 Cyberlindnera jadinii P08791 gene leu2
-
1.1.1.85 Eremothecium gossypii O60027 i.e. Eremothecium gossypii, gene leu2
-
1.1.1.85 Escherichia coli P30125 gene leuB
-
1.1.1.85 Leptospira interrogans P24015 gene leuB
-
1.1.1.85 Mycobacterium tuberculosis variant bovis P94929 gene leuB
-
1.1.1.85 Ogataea angusta P34733 gene leu2
-
1.1.1.85 Saccharomyces cerevisiae P87267 orf Ydr417C
-
1.1.1.85 Salmonella enterica subsp. enterica serovar Typhimurium P37412 gene leuB
-
1.1.1.85 Scheffersomyces stipitis O94114 gene leu2
-
1.1.1.85 Thermus aquaticus P24098 gene leuB
-
1.1.1.85 Thermus thermophilus P61494 gene leuB
-
1.1.1.85 Thermus thermophilus P61495 gene leuB
-
1.1.1.85 Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 P61494 gene leuB
-
1.1.1.85 Zymoseptoria tritici Q9Y897 i.e. Septoria tritici, gene leuC
-
1.1.1.85 [Candida] boidinii Q01987 gene leu2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 D-isocitrate + NAD+
-
 Escherichia coli 2-oxoglutarate + CO2 + NADH
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, e.g. L103, T105, A337, and T341, overview Escherichia coli ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Thermus thermophilus ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Leptospira interrogans ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Clostridium pasteurianum ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Bacteroides fragilis ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Brassica napus ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Arthrospira platensis ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Acidithiobacillus ferrooxidans ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Azotobacter vinelandii ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Agrobacterium tumefaciens ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Saccharomyces cerevisiae ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Aspergillus niger ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Zymoseptoria tritici ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Eremothecium gossypii ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Ogataea angusta ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Cyberlindnera jadinii ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview [Candida] boidinii ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Scheffersomyces stipitis ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Candida maltosa ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Mycobacterium tuberculosis variant bovis ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Thermus aquaticus ?
-
 ?
1.1.1.85 additional information substrate specificity-determining residues, overview Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
1.1.1.85 More three-dimensional structure comparison, overview Escherichia coli

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 IDH
-
 Escherichia coli
1.1.1.41 isocitrate dehydrogenase
-
 Escherichia coli
1.1.1.41 NAD-dependent isocitrate dehydrogenase
-
 Escherichia coli
1.1.1.85 IMDH
-
 Thermus thermophilus
1.1.1.85 IMDH
-
 Leptospira interrogans
1.1.1.85 IMDH
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 IMDH
-
 Clostridium pasteurianum
1.1.1.85 IMDH
-
 Bacteroides fragilis
1.1.1.85 IMDH
-
 Brassica napus
1.1.1.85 IMDH
-
 Arthrospira platensis
1.1.1.85 IMDH
-
 Acidithiobacillus ferrooxidans
1.1.1.85 IMDH
-
 Azotobacter vinelandii
1.1.1.85 IMDH
-
 Agrobacterium tumefaciens
1.1.1.85 IMDH
-
 Saccharomyces cerevisiae
1.1.1.85 IMDH
-
 Aspergillus niger
1.1.1.85 IMDH
-
 Zymoseptoria tritici
1.1.1.85 IMDH
-
 Eremothecium gossypii
1.1.1.85 IMDH
-
 Ogataea angusta
1.1.1.85 IMDH
-
 Cyberlindnera jadinii
1.1.1.85 IMDH
-
 [Candida] boidinii
1.1.1.85 IMDH
-
 Scheffersomyces stipitis
1.1.1.85 IMDH
-
 Candida maltosa
1.1.1.85 IMDH
-
 Escherichia coli
1.1.1.85 IMDH
-
 Mycobacterium tuberculosis variant bovis
1.1.1.85 IMDH
-
 Thermus aquaticus
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Thermus thermophilus
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Leptospira interrogans
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Clostridium pasteurianum
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Bacteroides fragilis
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Brassica napus
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Arthrospira platensis
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Acidithiobacillus ferrooxidans
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Azotobacter vinelandii
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Agrobacterium tumefaciens
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Saccharomyces cerevisiae
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Aspergillus niger
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Zymoseptoria tritici
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Eremothecium gossypii
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Ogataea angusta
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Cyberlindnera jadinii
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 [Candida] boidinii
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Scheffersomyces stipitis
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Candida maltosa
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Escherichia coli
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Mycobacterium tuberculosis variant bovis
1.1.1.85 NAD-dependent isopropylmalate dehydrogenase
-
 Thermus aquaticus
1.1.1.85 Ydr417cp
-
 Saccharomyces cerevisiae

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+
-
 Escherichia coli
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Thermus thermophilus
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Leptospira interrogans
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Salmonella enterica subsp. enterica serovar Typhimurium
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Clostridium pasteurianum
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Bacteroides fragilis
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Brassica napus
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Arthrospira platensis
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Acidithiobacillus ferrooxidans
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Azotobacter vinelandii
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Agrobacterium tumefaciens
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Saccharomyces cerevisiae
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Aspergillus niger
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Zymoseptoria tritici
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Eremothecium gossypii
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Ogataea angusta
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Cyberlindnera jadinii
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview [Candida] boidinii
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Scheffersomyces stipitis
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Candida maltosa
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Escherichia coli
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Mycobacterium tuberculosis variant bovis
1.1.1.85 NAD+ dependent on, cofactor specificity-determining residues, overview Thermus aquaticus