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Literature summary extracted from

  • Svedruzic, Z.M.; Spivey, H.O.
    Interaction between mammalian glyceraldehyde-3-phosphate dehydrogenase and L-lactate dehydrogenase from heart and muscle (2006), Proteins, 63, 501-511.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.2.1.12 cytosol
-
 Cavia porcellus 5829
-
1.2.1.12 cytosol
-
 Oryctolagus cuniculus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.2.1.12 142000
-
-
 Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.27 pyruvate + NADH + H+ Sus scrofa D-glyceraldehyde-3-phosphate dehydrogenase and L-lactate dehydrogenase have a functional interaction that can affect NAD+/NADH metabolism and glycolysis in living cells (S)-lactate + NAD+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.27 Sus scrofa
-
-
-
1.2.1.12 Cavia porcellus
-
-
-
1.2.1.12 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.27 heart
-
 Sus scrofa
-
1.1.1.27 muscle
-
 Sus scrofa
-
1.2.1.12 muscle
-
 Cavia porcellus
-
1.2.1.12 muscle
-
 Oryctolagus cuniculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.2.1.12 94
-
-
 Oryctolagus cuniculus
1.2.1.12 190
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.27 pyruvate + NADH + H+
-
 Sus scrofa (S)-lactate + NAD+
-
 ?
1.1.1.27 pyruvate + NADH + H+ D-glyceraldehyde-3-phosphate dehydrogenase and L-lactate dehydrogenase have a functional interaction that can affect NAD+/NADH metabolism and glycolysis in living cells Sus scrofa (S)-lactate + NAD+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.2.1.12 tetramer
-
 Cavia porcellus
1.2.1.12 tetramer
-
 Oryctolagus cuniculus

Synonyms

EC Number Synonyms Comment Organism
1.2.1.12 GAPDH
-
 Cavia porcellus
1.2.1.12 GAPDH
-
 Oryctolagus cuniculus
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase
-
 Cavia porcellus
1.2.1.12 glyceraldehyde-3-phosphate dehydrogenase
-
 Oryctolagus cuniculus
1.2.1.12 pmGAPDH
-
 Cavia porcellus
1.2.1.12 rmGAPDH
-
 Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.2.1.12 7.4
-
 activity assay Cavia porcellus
1.2.1.12 7.4
-
 activity assay Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.27 NADH
-
 Sus scrofa
1.2.1.12 NADH
-
 Cavia porcellus
1.2.1.12 NADH
-
 Oryctolagus cuniculus

pI Value

EC Number Organism Comment pI Value Maximum pI Value
1.2.1.12 Oryctolagus cuniculus
-
-
 8.4