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Literature summary extracted from

  • Ringer, K.L.; Davis, E.M.; Croteau, R.
    Monoterpene metabolism. Cloning, expression, and characterization of (-)-isopiperitenol/(-)-carveol dehydrogenase of peppermint and spearmint (2005), Plant Physiol., 137, 863-872.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.223 expressed in Escherichia coli Mentha x piperita
1.1.1.243 expressed in Escherichia coli Mentha spicata

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.82 soluble
-
 Mentha x piperita
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ Mentha x piperita pathways of monoterpene biosynthesis, overview (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ Mentha spicata pathways of monoterpene biosynthesis, overview (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+ Mentha x piperita the soluble NADPH-dependent, endocyclic double-bond reductase reduces (-)-isopiperitenone to (+)-cis-isopulegone, pathways of monoterpene biosynthesis, overview (+)-cis-isopulegone + NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+ Mentha spicata the soluble NADPH-dependent, endocyclic double-bond reductase reduces (-)-isopiperitenone to (+)-cis-isopulegone, pathways of monoterpene biosynthesis, overview (+)-cis-isopulegone + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.223 Mentha x piperita
-
 sterile cross between Mentha spicata and Mentha aquatica
-
1.1.1.243 Mentha spicata
-
-
-
1.3.1.81 Mentha spicata
-
-
-
1.3.1.81 Mentha x piperita
-
-
-
1.3.1.82 Mentha spicata
-
-
-
1.3.1.82 Mentha x piperita
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.223 (-)-trans-isopiperitenol + NADP+
-
 Mentha x piperita (-)-isopiperitenone + NADPH + H+
-
 ?
1.1.1.243 (-)-trans-isopiperitenol + NADP+
-
 Mentha spicata (-)-isopiperitenone + NADPH + H+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+
-
 Mentha spicata (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ pathways of monoterpene biosynthesis, overview Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ pathways of monoterpene biosynthesis, overview Mentha spicata (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.81 2 (+)-pulegone + 2 NADPH + 2 H+ the NADPH-dependent reductase reduces the conjugated double bond to yield both (-)-menthone and (+)-isomenthone Mentha x piperita (-)-menthone + (+)-isomenthone + 2 NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+
-
 Mentha x piperita (+)-cis-isopulegone + NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+
-
 Mentha spicata (+)-cis-isopulegone + NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+ the soluble NADPH-dependent, endocyclic double-bond reductase reduces (-)-isopiperitenone to (+)-cis-isopulegone, pathways of monoterpene biosynthesis, overview Mentha x piperita (+)-cis-isopulegone + NADP+
-
 ?
1.3.1.82 (-)-isopiperitenone + NADPH + H+ the soluble NADPH-dependent, endocyclic double-bond reductase reduces (-)-isopiperitenone to (+)-cis-isopulegone, pathways of monoterpene biosynthesis, overview Mentha spicata (+)-cis-isopulegone + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.223 (2)-isopiperitenol dehydrogenase
-
 Mentha x piperita
1.1.1.243 (-)-carveol dehydrogenase
-
 Mentha spicata
1.3.1.81 More the enzyme belongs to the distinct medium chain dehydrogenase/reductase superfamily Mentha x piperita
1.3.1.81 More the enzyme belongs to the distinct medium chain dehydrogenase/reductase superfamily Mentha spicata

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.223 NADP+
-
 Mentha x piperita
1.1.1.243 NADP+
-
 Mentha spicata
1.3.1.81 NADPH
-
 Mentha x piperita
1.3.1.81 NADPH
-
 Mentha spicata
1.3.1.82 NADPH
-
 Mentha spicata
1.3.1.82 NADPH dependent on Mentha x piperita