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Literature summary extracted from

  • Bergeron, S.; Chaplin, D.A.; Edwards, J.H.; Ellis, B.S.; Hill, C.L.; Holt-Tiffin, K.; Knight, J.R.; Mahoney, T.; Osborne, A.P.; Ruecroft, G.
    Nitrilase-catalyzed desymmetrization of 3-hydroxyglutaronitrile: preparation of a statin side-chain intermediate (2006), Org. Proc. Res. Dev., 10, 661-665.
No PubMed abstract available

Application

EC Number Application Comment Organism
3.5.5.7 synthesis an efficient, scaleable synthesis of ethyl (R)-4-cyano-3-hydroxybutyrate, a potential intermediate in the synthesis of Atorvastatin (Lipitor) involves nitrilase-catalyzed desymmetrization of 3-hydroxyglutaronitrile Pseudomonas fluorescens

Organism

EC Number Organism UniProt Comment Textmining
3.5.5.7 Pseudomonas fluorescens
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