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Literature summary extracted from

  • Klugmann, M.; Leichtlein, C.B.; Symes, C.W.; Serikawa, T.; Young, D.; During, M.J.
    Restoration of aspartoacylase activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease (2005), Mol. Ther., 11, 745-753.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.15
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.15 additional information restoration of deficient enzyme activity in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, phenotypes, overview Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.15 cytosol
-
 Homo sapiens 5829
-
3.5.1.15 cytosol
-
 Rattus norvegicus 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.15 37000
-
 determined by SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.15 N-acetylaspartate + H2O Homo sapiens aspartocylase deficiency results in elevated levels of substrate, brain edema and dysmyelination L-aspartate + acetate
-
 ?
3.5.1.15 N-acetylaspartic acid + H2O Rattus norvegicus restoration of deficient enzyme activity by enzyme expression in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, overview L-asparatate + acetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.15 Homo sapiens
-
-
-
3.5.1.15 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.15 brain
-
 Rattus norvegicus
-
3.5.1.15 neuron
-
 Homo sapiens
-
3.5.1.15 neuron
-
 Rattus norvegicus
-
3.5.1.15 oligodendrocyte
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.15 N-acetylaspartate + H2O aspartocylase deficiency results in elevated levels of substrate, brain edema and dysmyelination Homo sapiens L-aspartate + acetate
-
 ?
3.5.1.15 N-acetylaspartic acid + H2O
-
 Rattus norvegicus L-asparatate + acetate
-
 ?
3.5.1.15 N-acetylaspartic acid + H2O restoration of deficient enzyme activity by enzyme expression in CNS neurons does not ameliorate motor deficits and demyelination in a model of Canavan disease, which is caused by elevated levels of N-acetylaspartic acid, NAA, neuronal expression of ASPA can compensate for NAA-mediated neuronal hyperexcitation, but not for oligodebdrocyte dysfunciton, overview Rattus norvegicus L-asparatate + acetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.15 ASPA
-
 Rattus norvegicus
3.5.1.15 Aspartoacylase
-
 Homo sapiens