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Literature summary extracted from

  • Arampatzis, S.; Kadereit, B.; Schuster, D.; Balazs, Z.; Schweizer, R.A.; Frey, F.J.; Langer, T.; Odermatt, A.
    Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species (2005), J. Mol. Endocrinol., 35, 89-101.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.1.1.B40 drug development the enzyme is a target for inhibitor design and development Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.B40 expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells Rattus norvegicus
1.1.1.B40 expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells Mesocricetus auratus
1.1.1.B40 expression of FLAG-tagged isozyme 11beta-HSD1 in HEK-293 cells Homo sapiens
1.1.1.B40 expression of isozyme 11beta-HSD1 in HEK-293 cells Cavia porcellus
1.1.1.B40 isozyme 11beta-HSD1, expression in HEK-293 cells Mus musculus
1.1.1.B40 isozyme 11beta-HSD1, expression in HEK-293 cells Canis lupus familiaris

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.B40 2'-hydroxyflavanone
-
 Canis lupus familiaris
1.1.1.B40 2'-hydroxyflavanone
-
 Cavia porcellus
1.1.1.B40 2'-hydroxyflavanone
-
 Homo sapiens
1.1.1.B40 2'-hydroxyflavanone
-
 Mesocricetus auratus
1.1.1.B40 2'-hydroxyflavanone
-
 Mus musculus
1.1.1.B40 2'-hydroxyflavanone
-
 Rattus norvegicus
1.1.1.B40 abietic acid
-
 Canis lupus familiaris
1.1.1.B40 abietic acid
-
 Cavia porcellus
1.1.1.B40 abietic acid
-
 Homo sapiens
1.1.1.B40 abietic acid
-
 Mesocricetus auratus
1.1.1.B40 abietic acid
-
 Mus musculus
1.1.1.B40 abietic acid
-
 Rattus norvegicus
1.1.1.B40 carbenoxolone
-
 Canis lupus familiaris
1.1.1.B40 carbenoxolone
-
 Cavia porcellus
1.1.1.B40 carbenoxolone
-
 Homo sapiens
1.1.1.B40 carbenoxolone
-
 Mesocricetus auratus
1.1.1.B40 carbenoxolone
-
 Mus musculus
1.1.1.B40 carbenoxolone
-
 Rattus norvegicus
1.1.1.B40 chenodeoxycholic acid
-
 Canis lupus familiaris
1.1.1.B40 chenodeoxycholic acid
-
 Cavia porcellus
1.1.1.B40 chenodeoxycholic acid
-
 Homo sapiens
1.1.1.B40 chenodeoxycholic acid
-
 Mesocricetus auratus
1.1.1.B40 chenodeoxycholic acid
-
 Mus musculus
1.1.1.B40 chenodeoxycholic acid
-
 Rattus norvegicus
1.1.1.B40 flavanone
-
 Canis lupus familiaris
1.1.1.B40 flavanone
-
 Cavia porcellus
1.1.1.B40 flavanone
-
 Homo sapiens
1.1.1.B40 flavanone
-
 Mesocricetus auratus
1.1.1.B40 flavanone
-
 Mus musculus
1.1.1.B40 flavanone
-
 Rattus norvegicus
1.1.1.B40 glycyrrhetinic acid
-
 Canis lupus familiaris
1.1.1.B40 glycyrrhetinic acid
-
 Cavia porcellus
1.1.1.B40 glycyrrhetinic acid
-
 Homo sapiens
1.1.1.B40 glycyrrhetinic acid
-
 Mesocricetus auratus
1.1.1.B40 glycyrrhetinic acid
-
 Mus musculus
1.1.1.B40 glycyrrhetinic acid
-
 Rattus norvegicus
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Canis lupus familiaris
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Cavia porcellus
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Homo sapiens
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Mesocricetus auratus
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Mus musculus
1.1.1.B40 additional information inhibitory effects in intact cells and IC50 values, overview, structure-based pharmacophore models for isozyme 11beta-HSD1 inhibitors using crystal structure 1XU7, 1XU9, and 2 BEL Rattus norvegicus
1.1.1.B40 T0504
-
 Canis lupus familiaris
1.1.1.B40 T0504
-
 Cavia porcellus
1.1.1.B40 T0504
-
 Homo sapiens
1.1.1.B40 T0504
-
 Mesocricetus auratus
1.1.1.B40 T0504
-
 Mus musculus
1.1.1.B40 T0504
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.B40 0.00038
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Mus musculus
1.1.1.B40 0.00042
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Homo sapiens
1.1.1.B40 0.00043
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Cavia porcellus
1.1.1.B40 0.00045
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Mesocricetus auratus
1.1.1.B40 0.00052
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Mus musculus
1.1.1.B40 0.00052
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Homo sapiens
1.1.1.B40 0.00057
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Mesocricetus auratus
1.1.1.B40 0.00057
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Canis lupus familiaris
1.1.1.B40 0.00064
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Cavia porcellus
1.1.1.B40 0.00085
-
 11-Dehydrocorticosterone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Rattus norvegicus
1.1.1.B40 0.00136
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Rattus norvegicus
1.1.1.B40 0.00157
-
 cortisone pH 7.4, 37°C, recombinant isozyme 11beta-HSD1 Canis lupus familiaris

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.B40 32000
-
 x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE Cavia porcellus
1.1.1.B40 33000
-
 x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Mus musculus
1.1.1.B40 33000
-
 x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Rattus norvegicus
1.1.1.B40 33000
-
 x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Mesocricetus auratus
1.1.1.B40 35000
-
 x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE Canis lupus familiaris
1.1.1.B40 35000
-
 x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.B40 11-dehydrocorticosterone + NADPH Mus musculus isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH Rattus norvegicus isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH Canis lupus familiaris isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH Mesocricetus auratus isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH Homo sapiens isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH Cavia porcellus isozyme 11beta-HSD1 corticosterone + NADP+
-
 ?
1.1.1.B40 cortisol + NAD+ Homo sapiens isozyme 11beta-HSD2 cortisone + NADH
-
 ir
1.1.1.B40 cortisone + NADPH + H+ Mus musculus isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ Rattus norvegicus isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ Canis lupus familiaris isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ Mesocricetus auratus isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ Homo sapiens isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ Cavia porcellus isozyme 11beta-HSD1, activation cortisol + NADP+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.B40 Canis lupus familiaris
-
 poodle, isozyme 11beta-HSD1
-
1.1.1.B40 Cavia porcellus Q6QLL4 isozyme 11beta-HSD1; gene HSD11B1, isozyme 11beta-HSD1
-
1.1.1.B40 Homo sapiens P28845 isozyme 11beta-HSD2; isozyme 11beta-HSD2
-
1.1.1.B40 Homo sapiens P80365 isozyme 11beta-HSD1; isozyme 11beta-HSD1
-
1.1.1.B40 Mesocricetus auratus Q6R0J2 isozyme 11beta-HSD1; isozyme 11beta-HSD1
-
1.1.1.B40 Mus musculus
-
 isozyme 11beta-HSD1
-
1.1.1.B40 Rattus norvegicus
-
 isozyme 11beta-HSD1
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Mus musculus
a
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Rattus norvegicus
a
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Canis lupus familiaris
a
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Mesocricetus auratus
a
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Homo sapiens
a
1.1.1.B40 an 11beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH + H+ the three-dimensional organization of the hydrophobic substrate binding pocket is responsible for species-specific variability of activity with different substrates, overview Cavia porcellus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.B40 liver
-
 Canis lupus familiaris
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.B40 additional information
-
-
 Mus musculus
1.1.1.B40 additional information
-
-
 Rattus norvegicus
1.1.1.B40 additional information
-
-
 Canis lupus familiaris
1.1.1.B40 additional information
-
-
 Mesocricetus auratus
1.1.1.B40 additional information
-
-
 Homo sapiens
1.1.1.B40 additional information
-
-
 Cavia porcellus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Mus musculus corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Rattus norvegicus corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Canis lupus familiaris corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Mesocricetus auratus corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Homo sapiens corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1 Cavia porcellus corticosterone + NADP+
-
 ?
1.1.1.B40 11-dehydrocorticosterone + NADPH isozyme 11beta-HSD1, low activity Canis lupus familiaris corticosterone + NADP+
-
 ?
1.1.1.B40 2 7-oxocholesterol + 2 NADPH + 2 H+ isozyme 11beta-HSD1, stereospecific reaction Mesocricetus auratus 7beta-hydroxycholesterol + 7alpha-hydroxycholesterol + 2 NADP+
-
 ?
1.1.1.B40 7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction Mus musculus 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.B40 7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction Rattus norvegicus 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.B40 7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction Homo sapiens 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.B40 7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction, very low activity Canis lupus familiaris 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.B40 7-oxocholesterol + NADPH + H+ isozyme 11beta-HSD1, stereospecific reaction, very low activity Cavia porcellus 7beta-hydroxycholesterol + NADP+
-
 ?
1.1.1.B40 cortisol + NAD+ isozyme 11beta-HSD2 Homo sapiens cortisone + NADH
-
 ir
1.1.1.B40 cortisol + NAD+ isozyme 11beta-HSD2 catalyzes the reverse reaction with cofactor NAD+ Homo sapiens cortisone + NADH
-
 ir
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1 Mus musculus cortisol + NADP+
-
 r
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1 Rattus norvegicus cortisol + NADP+
-
 r
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Mus musculus cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Rattus norvegicus cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Canis lupus familiaris cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Mesocricetus auratus cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Homo sapiens cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, activation Cavia porcellus cortisol + NADP+
-
 ?
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, high activity Mesocricetus auratus cortisol + NADP+
-
 r
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, high activity Cavia porcellus cortisol + NADP+
-
 r
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, low activity Canis lupus familiaris cortisol + NADP+
-
 r
1.1.1.B40 cortisone + NADPH + H+ isozyme 11beta-HSD1, preferred substrate, high activity Homo sapiens cortisol + NADP+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.B40 ? x * 32000, recombinant isozyme 11beta-HSD1, SDS-PAGE Cavia porcellus
1.1.1.B40 ? x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Mus musculus
1.1.1.B40 ? x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Rattus norvegicus
1.1.1.B40 ? x * 33000, recombinant isozyme 11beta-HSD1, SDS-PAGE Mesocricetus auratus
1.1.1.B40 ? x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE Canis lupus familiaris
1.1.1.B40 ? x * 35000, recombinant isozyme 11beta-HSD1, SDS-PAGE Homo sapiens
1.1.1.B40 More structure molecular modeling Mus musculus
1.1.1.B40 More structure molecular modeling Rattus norvegicus
1.1.1.B40 More structure molecular modeling Canis lupus familiaris
1.1.1.B40 More structure molecular modeling Mesocricetus auratus
1.1.1.B40 More structure molecular modeling Homo sapiens
1.1.1.B40 More structure molecular modeling Cavia porcellus

Synonyms

EC Number Synonyms Comment Organism
1.1.1.B40 11beta-HSD1
-
 Mus musculus
1.1.1.B40 11beta-HSD1
-
 Rattus norvegicus
1.1.1.B40 11beta-HSD1
-
 Canis lupus familiaris
1.1.1.B40 11beta-HSD1
-
 Mesocricetus auratus
1.1.1.B40 11beta-HSD1
-
 Homo sapiens
1.1.1.B40 11beta-HSD1
-
 Cavia porcellus
1.1.1.B40 11beta-HSD2
-
 Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Mus musculus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Rattus norvegicus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Canis lupus familiaris
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Mesocricetus auratus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Homo sapiens
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 1
-
 Cavia porcellus
1.1.1.B40 11beta-hydroxysteroid dehydrogenase type 2
-
 Homo sapiens
1.1.1.B40 7-alpha-HCD
-
 Mesocricetus auratus
1.1.1.B40 7-alpha-hydroxycholesterol dehydrogenase
-
 Mesocricetus auratus
1.1.1.B40 corticosteroid 11-beta-dehydrogenase isozyme 1
-
 Mesocricetus auratus
1.1.1.B40 corticosteroid 11-beta-dehydrogenase isozyme 1
-
 Cavia porcellus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.B40 37
-
 assay at Mus musculus
1.1.1.B40 37
-
 assay at Rattus norvegicus
1.1.1.B40 37
-
 assay at Canis lupus familiaris
1.1.1.B40 37
-
 assay at Mesocricetus auratus
1.1.1.B40 37
-
 assay at Homo sapiens
1.1.1.B40 37
-
 assay at Cavia porcellus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.B40 7.4
-
 assay at Mus musculus
1.1.1.B40 7.4
-
 assay at Rattus norvegicus
1.1.1.B40 7.4
-
 assay at Canis lupus familiaris
1.1.1.B40 7.4
-
 assay at Mesocricetus auratus
1.1.1.B40 7.4
-
 assay at Homo sapiens
1.1.1.B40 7.4
-
 assay at Cavia porcellus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.B40 NAD+
-
 Homo sapiens
1.1.1.B40 NADP+
-
 Mus musculus
1.1.1.B40 NADP+
-
 Rattus norvegicus
1.1.1.B40 NADP+
-
 Canis lupus familiaris
1.1.1.B40 NADP+
-
 Mesocricetus auratus
1.1.1.B40 NADP+
-
 Homo sapiens
1.1.1.B40 NADP+
-
 Cavia porcellus
1.1.1.B40 NADPH
-
 Mus musculus
1.1.1.B40 NADPH
-
 Rattus norvegicus
1.1.1.B40 NADPH
-
 Canis lupus familiaris
1.1.1.B40 NADPH
-
 Mesocricetus auratus
1.1.1.B40 NADPH
-
 Homo sapiens
1.1.1.B40 NADPH
-
 Cavia porcellus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.B40 0.000006
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.000015
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.000025
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.000025
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.000028
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.00008
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.000082
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.00011
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.00012
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.00012
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.00023
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.00023
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.00025
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.00028
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.00029
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.0003
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.00033
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.00034
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.00035
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.00043
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.00044
-
 glycyrrhetinic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.00055
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.00059
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.00077
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.00094
-
 carbenoxolone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.0012
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.0018
-
 T0504 pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.002
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.0021
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.0021
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.0021
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.0025
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.003
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.0039
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.0049
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.0049
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.0052
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.0061
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.0064
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.007
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.007
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.0097
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.011
-
 abietic acid pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.015
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.017
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisone reduction Homo sapiens
1.1.1.B40 0.019
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.02
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.031
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of 11-dehydrocorticosterone reduction Homo sapiens
1.1.1.B40 0.031
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Cavia porcellus
1.1.1.B40 0.034
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mus musculus
1.1.1.B40 0.035
-
 chenodeoxycholic acid pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Mesocricetus auratus
1.1.1.B40 0.035
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Canis lupus familiaris
1.1.1.B40 0.05
-
 2'-hydroxyflavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.054
-
 flavanone pH 7.4, 37°C, isozyme 11beta-HSD1, inhibition of cortisol oxidation Rattus norvegicus
1.1.1.B40 0.2
-
 flavanone above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens
1.1.1.B40 0.2
-
 2'-hydroxyflavanone above, pH 7.4, 37°C, isozyme 11beta-HSD2, inhibition of cortisol oxidation Homo sapiens