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Literature summary extracted from

  • Nguyen, C.; Kasinathan, G.; Leal-Cortijo, I.; Musso-Buendia, A.; Kaiser, M.; Brun, R.; Ruiz-Perez, L.M.; Johansson, N.G.; Gonzalez-Pacanowska, D.; Gilbert, I.H.
    Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target (2005), J. Med. Chem., 48, 5942-5954.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.6.1.23 drug development the enzyme is a potential antiparasitic drug target Homo sapiens
3.6.1.23 drug development the enzyme is a potential antiparasitic drug target Leishmania donovani
3.6.1.23 drug development the enzyme is a potential antiparasitic drug target Plasmodium falciparum
3.6.1.23 drug development the enzyme is a potential antiparasitic drug target Leishmania major

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.23 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Homo sapiens
3.6.1.23 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Leishmania donovani
3.6.1.23 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Leishmania major
3.6.1.23 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Plasmodium falciparum
3.6.1.23 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
3.6.1.23 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania donovani
3.6.1.23 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania major
3.6.1.23 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3.6.1.23 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
3.6.1.23 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania donovani
3.6.1.23 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Leishmania major
3.6.1.23 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3.6.1.23 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Homo sapiens
3.6.1.23 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Leishmania donovani
3.6.1.23 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Leishmania major
3.6.1.23 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
3.6.1.23 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
3.6.1.23 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
3.6.1.23 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
3.6.1.23 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania donovani
3.6.1.23 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania major
3.6.1.23 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
3.6.1.23 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Homo sapiens
3.6.1.23 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Leishmania major
3.6.1.23 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Leishmania major
3.6.1.23 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
3.6.1.23 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania donovani
3.6.1.23 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Leishmania major
3.6.1.23 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
3.6.1.23 5'-tritylamino-2',5'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania major
3.6.1.23 5'-tritylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Homo sapiens
3.6.1.23 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Leishmania donovani
3.6.1.23 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Leishmania major
3.6.1.23 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 additional information inhibitor in vivo activity against the parasite, overview Homo sapiens
3.6.1.23 additional information inhibitor in vivo activity against the parasite, overview Leishmania donovani
3.6.1.23 additional information inhibitor in vivo activity against the parasite, overview Leishmania major
3.6.1.23 additional information inhibitor in vivo activity against the parasite, overview Plasmodium falciparum

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.23 Mg2+
-
 Homo sapiens
3.6.1.23 Mg2+
-
 Leishmania donovani
3.6.1.23 Mg2+
-
 Plasmodium falciparum
3.6.1.23 Mg2+
-
 Leishmania major

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.1.23 dUTP + H2O Homo sapiens
-
 dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Leishmania donovani
-
 dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Plasmodium falciparum
-
 dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O Leishmania major
-
 dUMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.23 Homo sapiens
-
-
-
3.6.1.23 Leishmania donovani
-
-
-
3.6.1.23 Leishmania major
-
-
-
3.6.1.23 Plasmodium falciparum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.23 dUTP + H2O
-
 Homo sapiens dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Leishmania donovani dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Plasmodium falciparum dUMP + diphosphate
-
 ?
3.6.1.23 dUTP + H2O
-
 Leishmania major dUMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.23 deoxyuridine triphosphate nucleotidohydrolase
-
 Homo sapiens
3.6.1.23 deoxyuridine triphosphate nucleotidohydrolase
-
 Leishmania donovani
3.6.1.23 deoxyuridine triphosphate nucleotidohydrolase
-
 Plasmodium falciparum
3.6.1.23 deoxyuridine triphosphate nucleotidohydrolase
-
 Leishmania major
3.6.1.23 dUTPase
-
 Homo sapiens
3.6.1.23 dUTPase
-
 Leishmania donovani
3.6.1.23 dUTPase
-
 Plasmodium falciparum
3.6.1.23 dUTPase
-
 Leishmania major

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.23 0.0002
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.0013
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.0028
-
 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.012
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.026
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3.6.1.23 0.046
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 0.058
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.067
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Plasmodium falciparum
3.6.1.23 0.082
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.088
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.089
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
3.6.1.23 0.099
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate
-
 Plasmodium falciparum
3.6.1.23 0.189
-
 5'-pentanoylamino-2',5'-dideoxyuridine
-
 Plasmodium falciparum
3.6.1.23 0.232
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate
-
 Homo sapiens
3.6.1.23 0.298
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 0.304
-
 5'-tritylamino-2',5'-dideoxyuridine
-
 Leishmania major
3.6.1.23 0.324
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine
-
 Homo sapiens
3.6.1.23 0.35
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
3.6.1.23 0.433
-
 5'-O-(1-adamantoyl)-2',3'-didehydro-2',3'-dideoxyuridine
-
 Leishmania major
3.6.1.23 0.799
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine
-
 Homo sapiens
3.6.1.23 0.808
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine
-
 Homo sapiens
3.6.1.23 0.909
-
 5'-O-triphenylsilyl-2'-deoxyuridine
-
 Homo sapiens
3.6.1.23 0.975
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine
-
 Plasmodium falciparum
3.6.1.23 1
-
 5'-O-triphenylsilyl-2'-deoxyuridine above Leishmania major
3.6.1.23 1
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Homo sapiens
3.6.1.23 1
-
 2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Leishmania major
3.6.1.23 1
-
 5'-pentanoylamino-2',5'-dideoxyuridine above Homo sapiens
3.6.1.23 1
-
 5'-pentanoylamino-2',5'-dideoxyuridine above Leishmania major
3.6.1.23 1
-
 3'-O-tert-butyldimethylsilyl-5'-O-sulfamoyl-2'-deoxyuridine above Leishmania major
3.6.1.23 1
-
 3'-O-tert-butyldimethylsilyl-2',5'-dideoxyuridine 5'-N-diphenylphosphoramidate above Leishmania major
3.6.1.23 1
-
 5'-tert-butyldiphenylsilyloxy-2',3'-dideoxy-3'-fluorouridine above Leishmania major
3.6.1.23 1
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine above Homo sapiens
3.6.1.23 1
-
 5'-O-triphenylsilyl-2',3'-dideoxy-3'-fluorouridine above Leishmania major
3.6.1.23 1
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine above Homo sapiens
3.6.1.23 1
-
 5'-tritylamino-3'-fluoro-2',3',5'-trideoxyuridine above Leishmania major
3.6.1.23 1
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate above Homo sapiens
3.6.1.23 1
-
 2',3'-didehydro-2',3'-dideoxyuridine 5'-diphenyl phosphate above Leishmania major
3.6.1.23 1
-
 5'-O-sulfamoylcarbamoyl-2',3'-didehydro-2',3'-dideoxyuridine above Leishmania major
3.6.1.23 1
-
 5'-O-triphenylsilyl-2',3'-didehydro-2',3'-dideoxyuridine above Homo sapiens